Description

2-Chloro-3-Fluorotoluene is a versatile halogenated aromatic building block of significant importance in advanced organic synthesis. Its unique substitution pattern makes it a critical intermediate for constructing complex molecules, particularly in the pharmaceutical and agrochemical sectors. This compound is essential for researchers and manufacturers developing active pharmaceutical ingredients (APIs), crop protection agents, and specialty materials.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and anti-inflammatory applications.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the chloro-fluoro substitution pattern enhances biological activity and environmental profile.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated aromatic compounds used in electronic display technologies.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Negishi) and nucleophilic substitution reactions to introduce functionalized toluenes into more complex structures.
• Dye & Pigment Intermediate: Utilized in the manufacture of specialized halogenated dyes and pigments for high-performance applications.

Basic Information

Product Name	2-Chloro-3-Fluorotoluene
CAS No.	116850-28-3
Molecular Formula	C7H6ClF
Molecular Weight	144.57 g/mol
Synonyms	1-Chloro-2-fluoro-3-methylbenzene; 3-Methyl-2-chlorofluorobenzene; 2-Chloro-3-fluoro-1-methylbenzene; o-Chloro-m-fluorotoluene; 2-Chloro-3-fluoromethylbenzene; Toluene, 2-chloro-3-fluoro-; 2-Fluoro-3-chlorotoluene
EINECS	Contact for details

Quality Control

Our 2-Chloro-3-Fluorotoluene is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support cGMP and ISO standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and bases. Recommended storage temperature is between 15°C and 25°C. Keep container tightly sealed when not in use to prevent moisture absorption and volatilization.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Total impurities ≤ 2.0%
Density (20°C)	~1.20 g/cm³
Boiling Point	~185-190°C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.