Description

Inositol 1,4-Bisphosphate 5-Phosphorothioate is a high-purity, chemically modified inositol phosphate derivative where a sulfur atom replaces an oxygen atom at the 5-phosphate position, creating a phosphorothioate linkage. This modification confers enhanced stability against phosphatases and makes it a critical biochemical tool for studying intracellular signaling pathways, particularly those involving inositol phosphates and phospholipase C. It is primarily utilized by research institutions, pharmaceutical R&D departments, and diagnostic kit manufacturers for mechanistic studies, enzyme inhibition assays, and as a reference standard.

Application

• Biochemical Research: As a stable analog and potent inhibitor in studies of inositol phosphate metabolism and phosphoinositide signaling cascades.
• Enzymology: Substrate or inhibitor for phosphatases and kinases involved in the inositol phosphate cycle, such as inositol polyphosphate 5-phosphatases.
• Pharmaceutical Development: Tool compound for target validation and high-throughput screening in drug discovery programs focused on metabolic and neurological disorders.
• Cell Signaling Studies: Used to modulate intracellular calcium release and investigate receptor-mediated signal transduction pathways.
• Diagnostic Reagent Manufacturing: Component in enzymatic assay kits for research and clinical diagnostics.
• Reference Standard: High-purity material for analytical method development, calibration, and quality control in laboratory settings.

Basic Information

Product Name	Inositol 1,4-Bisphosphate 5-Phosphorothioate
CAS No.	116778-73-5
Molecular Formula	C6H14O17P3S
Molecular Weight	507.14 g/mol
Synonyms	Ins(1,4)P2 5-PS; D-myo-Inositol 1,4-bisphosphate 5-phosphorothioate; 1,4-IP2 5-thiophosphate; Inositol 1,4-bis(phosphate) 5-thiophosphate; 1D-myo-Inositol 1,4-bis(dihydrogen phosphate) 5-(phosphorothioate); PtdIns(4,5)P2 analog; Phosphorothioate analog of Ins(1,4,5)P3
EINECS	Contact for details

Quality Control

Our Inositol 1,4-Bisphosphate 5-Phosphorothioate is manufactured under controlled conditions to ensure batch-to-batch consistency and high chemical purity. Each lot undergoes rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity, purity, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your research and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 3.0%
Solubility	Soluble in water, slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.