Description

Acetaminophen Cysteinylglycine is a specialized biochemical conjugate of the common analgesic acetaminophen (paracetamol) and the dipeptide cysteinylglycine. This compound is of significant interest as a key metabolite in the study of acetaminophen's metabolic pathways and its associated hepatotoxicity. It serves as a critical reference standard and research material for pharmaceutical development, toxicology studies, and advanced biochemical analysis. Researchers and quality control laboratories in the pharmaceutical and life sciences sectors require this high-purity compound for method validation and investigative studies.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantification and identification of acetaminophen metabolites in biological matrices.
• Toxicology and Metabolism Research: Essential for studying the biotransformation pathways of acetaminophen, particularly its conjugation with glutathione and subsequent breakdown products.
• Biomarker Development: Employed in the development and validation of analytical assays (e.g., LC-MS/MS, HPLC) to detect drug-induced liver injury (DILI) biomarkers.
• Drug Safety and Pharmacokinetics: Supports ADME (Absorption, Distribution, Metabolism, Excretion) studies to understand the safety profile of acetaminophen and related compounds.
• Academic and Institutional Research: A key reagent for universities and research institutes conducting studies in pharmacology, medicinal chemistry, and biochemical toxicology.

Basic Information

Product Name	Acetaminophen Cysteinylglycine
CAS No.	116709-74-1
Molecular Formula	C14H19N3O5S
Molecular Weight	341.38 g/mol
Synonyms	N-Acetyl-p-aminophenol Cysteinylglycine; Paracetamol Cysteinylglycine; APAP-Cys-Gly; Acetaminophen-Cys-Gly Conjugate; 4'-Hydroxyacetanilide cysteinylglycine; N-(4-Hydroxyphenyl)acetamide cysteinylglycine; S-(5-Acetamido-2-hydroxyphenyl)-L-cysteinylglycine
EINECS	Contact for details

Quality Control

Our Acetaminophen Cysteinylglycine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS), to ensure it meets the exacting standards required for research and reference applications. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, impurities, and batch-specific data.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.