Description

5-Amino-15N-Levulinic Acid Hcl is a stable isotope-labeled derivative of 5-aminolevulinic acid, where the nitrogen atom at the 15-position is enriched with the 15N isotope. This compound serves as a critical internal standard and tracer in advanced mass spectrometry and metabolic pathway analysis, enabling precise quantification and mechanistic studies. It is essential for researchers and manufacturers in pharmaceutical development, clinical diagnostics, and agricultural chemistry who require high-fidelity isotopic labeling for their analytical and synthetic protocols.

Application

• Used as an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) for the accurate quantification of 5-aminolevulinic acid and related metabolites in biological samples.
• Employed as a stable isotope tracer in metabolic flux analysis to study the heme biosynthesis pathway and porphyrin metabolism in plant, animal, and microbial systems.
• Facilitates research in photodynamic therapy (PDT) and diagnostic agents, helping to elucidate the pharmacokinetics and biodistribution of ALA-based compounds.
• Applied in the development and validation of clinical diagnostic assays for disorders related to porphyrin metabolism, such as porphyrias.
• Serves as a labeled precursor in the synthesis of complex isotopically labeled molecules for use in drug discovery and development.
• Utilized in agricultural research to study chlorophyll biosynthesis and plant growth regulation mechanisms.

Basic Information

Product Name	5-Amino-15N-Levulinic Acid Hcl
CAS No.	116571-80-3
Molecular Formula	C5H1015NO3 • HCl
Molecular Weight	184.60 g/mol (for 15N labeled form)
Synonyms	5-ALA-15N hydrochloride; δ-Aminolevulinic-15N Acid Hydrochloride; 5-Amino-4-oxopentanoic-15N Acid Hydrochloride; 5-ALA-15N HCl; 4-Oxo-5-aminopentanoic-15N Acid Hydrochloride; (15N)5-Aminolevulinic Acid Hydrochloride; ALA-15N HCl
EINECS	Contact for details

Quality Control

Every batch of our 5-Amino-15N-Levulinic Acid Hcl is produced and analyzed under strict quality management protocols. We guarantee high chemical and isotopic purity, with comprehensive testing that includes assay, isotopic enrichment verification, and impurity profiling. Certificates of Analysis (COA) detailing all specifications, including HPLC purity, 1H/13C NMR, and mass spectrometry data, are provided to ensure traceability and compliance with your research and production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (15N)	≥ 98 atom %
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.