Description

Nor-6-Oxycodol is a key pharmaceutical intermediate and reference standard of significant importance in modern medicinal chemistry and analytical research. Its primary value lies in its structural relationship to other thebaine-derived compounds, making it a critical building block for the synthesis and quality control of more complex active pharmaceutical ingredients (APIs). This compound is essential for research laboratories, pharmaceutical manufacturers, and analytical service providers focused on opioid chemistry, forensic analysis, and the development of controlled substance standards.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of more complex opioid analgesics and their derivatives for research purposes.
• Reference Standard: Used as a high-purity certified reference material (CRM) for the qualitative and quantitative analysis of related substances in forensic toxicology and pharmaceutical quality control laboratories.
• Metabolite Studies: Employed in pharmacological and clinical research as a standard for identifying and quantifying metabolic pathways of related therapeutic agents.
• Impurity Profiling: Critical for the identification and control of process-related impurities and degradation products during the manufacture of related APIs, ensuring product safety and regulatory compliance.
• Academic & R&D: Utilized in university and institutional research settings for studying structure-activity relationships (SAR) within the class of semi-synthetic opioids.
• Method Development: Acts as a standard compound for developing and validating advanced analytical methods, including HPLC, LC-MS, and GC-MS, in compliance with ICH guidelines.

Basic Information

Item	Detail
Product Name	Nor-6-Oxycodol
CAS No.	116499-16-2
Molecular Formula	C17H19NO4
Molecular Weight	301.34 g/mol
Synonyms	14-Hydroxydihydrocodeinone; 6-O-Desmethyloxycodone; Noroxycodone; 4,5α-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one; 14-Hydroxycodeinone; O-Desmethyloxycodone; Nor-6-Oxycodone; 6-Noroxycodol
EINECS	Contact for details

Quality Control

Every batch of Nor-6-Oxycodol is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to support its use as a reference standard and high-purity intermediate. Our products undergo rigorous quality testing, including identity confirmation by spectroscopic methods (IR, NMR, MS) and purity determination by chromatographic techniques (HPLC), to ensure compliance with exacting research and pharmaceutical standards. A detailed Certificate of Analysis (COA) is supplied with each shipment, and custom synthesis to meet specific purity or packaging requirements is available.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled and stored accordingly to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5% w/w
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.