Description

Acetylalanyl-Prolyl-Valyl-Trifluoromethyl Ketone CAS NO 116380-62-2 is a synthetic peptide derivative featuring a trifluoromethyl ketone (TFMK) warhead, designed as a potent and selective inhibitor of serine and cysteine proteases. This compound is critical for biochemical research and pharmaceutical development, enabling precise modulation of enzymatic activity. It is primarily utilized by researchers in medicinal chemistry, biochemistry, and drug discovery for studying protease mechanisms and developing novel therapeutic agents.

Application

• Protease Inhibition Research: Serves as a key biochemical tool for investigating the activity and inhibition kinetics of specific proteases like elastase, cathepsin, and chymase.
• Medicinal Chemistry & Drug Discovery: Used as a lead compound or intermediate in the development of new therapeutic agents targeting inflammatory diseases, cancer, and viral infections.
• Biochemical Assay Development: Employed in high-throughput screening (HTS) assays to identify and characterize new protease inhibitors.
• Enzyme Mechanism Studies: Facilitates detailed studies on enzyme active sites and catalytic mechanisms due to its covalent, reversible binding characteristics.
• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for quality control and analytical method validation in pharmaceutical R&D.

Basic Information

Product Name	Acetylalanyl-Prolyl-Valyl-Trifluoromethyl Ketone
CAS No.	116380-62-2
Molecular Formula	C20H29F3N4O5
Molecular Weight	462.46 g/mol
Synonyms	Ac-Ala-Pro-Val-CF3; Acetyl-Ala-Pro-Val-trifluoromethyl ketone; APV-CF3; N-Acetyl-L-alanyl-L-prolyl-L-valyl trifluoromethyl ketone; TFMK Inhibitor (APV); Protease Inhibitor 116380-62-2; L-Valine, N-acetyl-L-alanyl-L-prolyl-, 1,1,1-trifluoro-4-methyl-3-oxopentyl ester
EINECS	Contact for details

Quality Control

Our Acetylalanyl-Prolyl-Valyl-Trifluoromethyl Ketone is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency suitable for research and development. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, freezer environment. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.