Description

Tyrphostin AG 1288 is a potent and selective inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase. This compound is a critical research tool for studying signal transduction pathways, cellular proliferation, and apoptosis in various disease models. It is primarily utilized by researchers and scientists in the fields of oncology, biochemistry, and pharmacology for target validation, drug discovery, and mechanistic studies.

Application

• Biochemical Research: Used as a selective EGFR tyrosine kinase inhibitor to study receptor-mediated signaling cascades and their role in cell growth and differentiation.
• Oncology Research: Employed in in vitro and in vivo studies to investigate the effects of EGFR inhibition on tumor cell proliferation and survival.
• Drug Discovery & Development: Serves as a reference compound and pharmacological tool for screening and developing novel targeted cancer therapeutics.
• Cellular & Molecular Biology: Applied in experiments to elucidate the mechanisms of apoptosis and to dissect specific pathways involved in cellular responses to growth factors.
• Academic & Pharmaceutical R&D: A key reagent for basic scientific research and pre-clinical development stages within university laboratories and pharmaceutical companies.

Basic Information

Product Name	Tyrphostin AG 1288
CAS No.	116313-73-6
Molecular Formula	C₁₇H₁₄N₂O₃
Molecular Weight	294.31 g/mol
Synonyms	AG 1288; AG-1288; AG1288; Tyrphostin B44; 4-Hydroxy-3,5-dimethoxybenzylidene malononitrile; 3,5-Dimethoxy-4-hydroxybenzylidenemalononitrile; EGFR Inhibitor AG 1288; (E)-2-(3,5-Dimethoxy-4-hydroxybenzylidene)malononitrile
EINECS	Contact for details

Quality Control

Our Tyrphostin AG 1288 is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and structural identity. Certificates of Analysis (COA) detailing purity, impurities, and analytical results are provided to guarantee consistency and reliability for your research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and light-sensitive (store away from light). For long-term storage, consider desiccation and under inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥98.0%
Water Content	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.