Description

Ethyl 6-Fluoro-Nicotinate is a high-value fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its core value lies in the strategic introduction of fluorine and the versatile ethyl ester group, enabling precise molecular modifications for enhanced biological activity and physicochemical properties. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients and fine-tuning compound libraries.

Application

• Pharmaceutical Intermediate: A key synthon for the development of fluorinated drug candidates, including kinase inhibitors and central nervous system (CNS) active agents.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atom improves metabolic stability and bioavailability.
• Chemical Research & Development: Serves as a versatile precursor for further functionalization, such as hydrolysis to the corresponding acid or amidation reactions.
• Ligand and Material Science: Employed in the synthesis of complex ligands for catalysis and in the development of specialty materials requiring fluorinated aromatic components.

Basic Information

Product Name	Ethyl 6-Fluoro-Nicotinate
CAS No.	116241-59-9
Molecular Formula	C8H8FNO2
Molecular Weight	169.15 g/mol
Synonyms	6-Fluoronicotinic Acid Ethyl Ester; Ethyl 6-Fluoropyridine-3-carboxylate; 3-Carbethoxy-6-fluoropyridine; 6-Fluoro-3-pyridinecarboxylic Acid Ethyl Ester; 6-Fluoronicotinic Acid Ethyl Ester; Ethyl 6-Fluoro-3-pyridinecarboxylate
EINECS	Contact for details

Quality Control

Our Ethyl 6-Fluoro-Nicotinate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong bases and fluorides. The container should be kept tightly sealed to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.