Description

18-Hydroxycamptothecin is a potent semi-synthetic derivative of the natural alkaloid camptothecin, known for its significant role as a topoisomerase I inhibitor. This compound is crucial for advanced pharmaceutical research and development, particularly in the field of oncology, due to its enhanced solubility and targeted therapeutic potential compared to its parent molecule. It is primarily sought by pharmaceutical manufacturers, academic research institutions, and biotechnology companies engaged in the development of novel chemotherapeutic agents and targeted drug delivery systems.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of next-generation anticancer drugs and prodrugs.
• Oncology Research: Used as a reference standard and active pharmaceutical ingredient (API) in preclinical and clinical studies targeting various solid tumors.
• Biochemical Tool: Employed in molecular biology and pharmacology labs to study topoisomerase I inhibition mechanisms and cell apoptosis pathways.
• Drug Formulation Development: Utilized in R&D for creating liposomal, nanoparticle, or other advanced delivery systems to improve bioavailability and reduce side effects.
• Combinatorial Therapy Studies: Investigated in combination with other chemotherapeutic agents to evaluate synergistic effects and overcome drug resistance.

Basic Information

Product Name	18-Hydroxycamptothecin
CAS No.	116139-46-9
Molecular Formula	C20H16N2O6
Molecular Weight	380.35 g/mol
Synonyms	10-Hydroxycamptothecin; (S)-10-Hydroxycamptothecin; 10-HCPT; SN-38 Precursor; 10-Hydroxy-20(S)-camptothecin; (19S)-10-Hydroxycamptothecin; 18-HCPT; Irinotecan Active Metabolite Precursor
EINECS	Contact for details

Quality Control

Our 18-Hydroxycamptothecin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identification by spectroscopic methods, to ensure it meets the stringent requirements for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or under refrigeration (2-8°C) for long-term stability, as specified. The container should be kept in a dry, well-ventilated area away from incompatible materials.

Specification

Item	Specification
Appearance	Yellow to light yellow powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Specific Rotation	[α]20/D: Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.