Description

1-(Bromomethyl)-3-Methyl-5-(Trifluoromethyl)Benzene is a versatile and high-value aromatic building block characterized by its reactive benzyl bromide and electron-withdrawing trifluoromethyl group. This compound is essential for introducing the 3-methyl-5-(trifluoromethyl)benzyl moiety into target molecules, a modification that can significantly enhance lipophilicity, metabolic stability, and binding affinity. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of advanced intermediates and active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group improves biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for advanced functional materials, contributing to the molecular framework of liquid crystals and organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: The benzyl bromide functionality makes it a suitable substrate for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to create complex biaryl structures.
• Ligand & Catalyst Development: Employed in the preparation of specialized ligands and organocatalysts for asymmetric synthesis and polymerization processes.
• Fluorine Chemistry Research: A valuable reagent for studying structure-activity relationships (SAR) in fluorine-containing compounds due to its defined substitution pattern.

Basic Information

Product Name	1-(Bromomethyl)-3-Methyl-5-(Trifluoromethyl)Benzene
CAS No.	116070-36-1
Molecular Formula	C9H8BrF3
Molecular Weight	253.06 g/mol
Synonyms	3-Methyl-5-(trifluoromethyl)benzyl bromide; α-Bromo-3-methyl-5-(trifluoromethyl)toluene; (3-Methyl-5-(trifluoromethyl)phenyl)methyl bromide; 5-(Trifluoromethyl)-3-methylbenzyl bromide; 1-Bromomethyl-3-methyl-5-trifluoromethylbenzene; 3-Methyl-α-bromo-5-(trifluoromethyl)toluene
EINECS	Contact for details

Quality Control

Every batch of 1-(Bromomethyl)-3-Methyl-5-(Trifluoromethyl)Benzene is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the compound meets the high-purity standards required for research and scale-up applications. A detailed Certificate of Analysis (COA) confirming identity, purity, and impurity profile by techniques such as HPLC, GC, NMR, and IR spectroscopy is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic and light-sensitive nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation and moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.