Description

Philanthotoxin 343 Tris-Trifluoroacetate is a potent, non-competitive antagonist of ionotropic glutamate receptors, specifically targeting the AMPA and kainate subtypes. This high-purity biochemical is critical for advanced neuroscience research, enabling the study of synaptic transmission, neuronal excitability, and excitotoxicity. It is an essential tool for pharmaceutical R&D teams, academic researchers, and diagnostic developers focused on neurological disorders, neurodegenerative diseases, and the development of novel neuroprotective agents.

Application

• Neuroscience Research: Fundamental tool for studying AMPA and kainate receptor function and pharmacology in vitro and in vivo.
• Drug Discovery & Development: Used as a reference standard and pharmacological probe in high-throughput screening (HTS) assays for identifying new neuroactive compounds.
• Mechanistic Studies: Investigates the role of glutamate receptors in processes such as long-term potentiation (LTP), learning, memory, and excitotoxic cell death.
• Neuroprotection Research: Serves as a model compound to study excitotoxicity and evaluate potential neuroprotective therapies for stroke, trauma, and neurodegenerative conditions.
• Academic & Institutional Labs: Essential reagent for graduate and post-doctoral research projects in molecular and cellular neuroscience.
• Diagnostic Development: Potential use in developing assays for receptor profiling and neurological disease biomarker research.

Basic Information

Product Name	Philanthotoxin 343 Tris-Trifluoroacetate
CAS No.	115976-93-7
Molecular Formula	C₂₄H₄₅N₇O₇ • 3C₂HF₃O₂
Molecular Weight	~933.8 g/mol (as TFA salt)
Synonyms	PhTX-343; Philanthotoxin-343; Philanthotoxin 343; N-[(2S)-5-[[(2S)-5-[[(2S)-5-Amino-1-[[(2S)-5-amino-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-[[(4-hydroxyphenyl)methyl]amino]-1-oxopentan-2-yl]-4-hydroxybenzamide tris(2,2,2-trifluoroacetate); Argiotoxin-636; AR-636
EINECS	Contact for details

Quality Control

Every batch of Philanthotoxin 343 Tris-Trifluoroacetate is manufactured and analyzed under strict quality management protocols to ensure identity, purity, and consistency for sensitive research applications. Our standard analytical package includes comprehensive characterization by HPLC, MS, and NMR. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with our stringent in-house specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This compound is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.