Description

Philanthotoxin 433 Trifluoroacetate is a synthetic, non-proteinaceous neurotoxin analog that acts as a potent and selective non-competitive antagonist of ionotropic glutamate receptors, particularly the AMPA and kainate subtypes. This compound is a critical research tool for neuroscientists studying excitatory synaptic transmission, neuronal plasticity, and the mechanisms underlying neurological disorders. It is primarily utilized in academic, pharmaceutical, and biotechnology research settings for electrophysiological studies, receptor characterization, and the development of novel neuroprotective agents.

Application

• Neuroscience Research: A key pharmacological tool for blocking ionotropic glutamate receptors (AMPA/kainate) in electrophysiology experiments to study synaptic function and neuronal excitability.
• Receptor Pharmacology: Used in in vitro assays to characterize and subtype glutamate receptors, aiding in the understanding of receptor kinetics and antagonist binding sites.
• Neuroprotection Studies: Employed in models of excitotoxicity to investigate pathways of neuronal cell death and to screen potential therapeutic compounds for conditions like stroke, epilepsy, and neurodegenerative diseases.
• Insect Neurobiology: Serves as a reference compound in studies of arthropod nervous systems, given its origin from wasp venom, for comparative neurophysiology.
• Drug Discovery: Acts as a lead compound or template for the design and synthesis of new neuroactive agents targeting glutamate receptors.

Basic Information

Product Name	Philanthotoxin 433 Trifluoroacetate
CAS No.	115976-91-5
Molecular Formula	C₂₄H₄₃N₇O₅ • C₂HF₃O₂
Molecular Weight	Contact for details
Synonyms	PhTX-433; Philanthotoxin-433; Philanthotoxin 433; N-[(2S)-5-[[(2S)-5-[[(2S)-2-Amino-5-guanidinopentanoyl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]-1-naphthamide trifluoroacetate; 1-Naphthalenecarboxamide, N-[(2S)-5-[[(2S)-5-[[(2S)-2-amino-5-[(aminoiminomethyl)amino]-1-oxopentyl]amino]-1-oxopentyl]amino]-1-oxopentyl]-, (2S)-, 2,2,2-trifluoroacetate
EINECS	Contact for details

Quality Control

Our Philanthotoxin 433 Trifluoroacetate is produced and handled under strict quality protocols to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot is characterized by advanced analytical techniques including HPLC, MS, and NMR to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your research documentation and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥95%
Assay (Titration)	≥98% (anhydrous basis)
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.