Description

n-(Deoxyguanosin-8-Yl)-2-Amino-3-Methylimidazolo(4,5-F)Quinoline CAS NO 115747-35-8 is a specific DNA adduct formed from the reaction of deoxyguanosine with the heterocyclic amine 2-amino-3-methylimidazo[4,5-f]quinoline (IQ), a known mutagen and carcinogen found in cooked meats. This compound is of critical importance as a biomarker for assessing human exposure to dietary mutagens and for studying the molecular mechanisms of chemical carcinogenesis. It is primarily needed by research institutions, diagnostic laboratories, and pharmaceutical companies engaged in toxicology studies, cancer research, and the development of analytical standards for food safety and environmental health monitoring.

Application

• Biomarker Research: Used as a reference standard to quantify IQ-DNA adducts in biological samples (e.g., urine, tissue) for exposure assessment in epidemiological studies.
• Mechanistic Toxicology: Essential for in vitro and in vivo studies investigating the genotoxic pathways, DNA repair mechanisms, and mutagenic potency of heterocyclic aromatic amines (HAAs).
• Analytical Method Development: Serves as a critical calibrant and quality control material in advanced analytical techniques such as LC-MS/MS, 32P-postlabeling, and immunoassays.
• Carcinogenesis Studies: Employed in research to understand the role of specific DNA adducts in the initiation and progression of cancers, particularly those linked to diet.
• Reference Standard Production: Supplied to manufacturers of diagnostic kits and certified reference materials (CRMs) for food safety and clinical diagnostics.
• Regulatory Science: Supports safety evaluations and risk assessments conducted by public health and regulatory agencies.

Basic Information

Product Name	n-(Deoxyguanosin-8-Yl)-2-Amino-3-Methylimidazolo(4,5-F)Quinoline
CAS No.	115747-35-8
Molecular Formula	C₂₂H₂₂N₈O₄
Molecular Weight	462.46 g/mol
Synonyms	N-(Deoxyguanosin-8-yl)-IQ; 8-(Deoxyguanosin-N²-yl)-2-amino-3-methylimidazo[4,5-f]quinoline; IQ-C8-dG Adduct; dG-C8-IQ; 2-Amino-3-methylimidazo[4,5-f]quinoline-deoxyguanosine adduct; DNA-IQ Adduct; CAS 115747-35-8
EINECS	Contact for details

Quality Control

Every batch of our n-(Deoxyguanosin-8-Yl)-2-Amino-3-Methylimidazolo(4,5-F)Quinoline is manufactured and analyzed under strict quality protocols to ensure identity, purity, and stability for research use. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, providing detailed results from multiple orthogonal analytical methods.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. This compound is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to ambient conditions or light may lead to degradation. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Off-white to light tan solid
Identification (HPLC-MS)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 3.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.