Description

10-Propargyl-5-Deazafolic Acid is a synthetic folate analog and a key intermediate in the development of novel enzyme inhibitors and targeted therapeutics. This compound matters for its role as a versatile building block in medicinal chemistry, particularly for creating potent inhibitors of folate-dependent enzymes like thymidylate synthase. Pharmaceutical researchers and fine chemical manufacturers need it for the research and development of new anticancer agents, antimicrobials, and for advanced biochemical studies.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel antifolate drugs targeting cancer and infectious diseases.
• Biochemical Research: Used as a tool compound in enzymatic studies, particularly for investigating folate metabolism and thymidylate synthase inhibition.
• Medicinal Chemistry: Serves as a core scaffold for structure-activity relationship (SAR) studies to develop new therapeutic agents.
• Anticancer Agent Development: A precursor in the synthesis of potential chemotherapeutic compounds that interfere with DNA synthesis in rapidly dividing cells.
• Academic & Institutional Research: Utilized in university and research institute labs for fundamental studies in biochemistry and drug discovery.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis and scale-up projects.

Basic Information

Product Name	10-Propargyl-5-Deazafolic Acid
CAS No.	115722-29-7
Molecular Formula	C23H23N7O5
Molecular Weight	477.48 g/mol
Synonyms	10-Propargyl-5-deazafolic acid; 5-Deaza-10-propargylfolic acid; 10-Propargyl-5-deaza folate; N-[4-[[(2-Amino-3,4,7,8-tetrahydro-4-oxo-10-propargyl-5H-pyrimido[4,5-b][1,4]diazepin-6-yl)methyl]amino]benzoyl]-L-glutamic acid; 5,10-Dideazapteroylpropargylglutamate; DDATHFPG; Propargyl-DDATHF; CB3717 Propargyl Analog
EINECS	Contact for details

Quality Control

Our 10-Propargyl-5-Deazafolic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.