Description

1,4-(Bis-Glutathion-S-Yl)-1,2,3,4-Tetrachloro-1,3-Butadiene CAS NO 115664-52-3 is a specialized, high-purity biochemical reference standard and research chemical. This compound is of significant value for advanced toxicological and metabolic pathway studies, particularly in investigating the biotransformation and detoxification mechanisms of halogenated hydrocarbons. It is primarily required by research institutions, pharmaceutical R&D laboratories, and analytical service providers focused on glutathione conjugation and the formation of reactive metabolite adducts.

Application

• Biochemical Research Standard: Used as a certified reference material for calibrating analytical instruments (LC-MS, HPLC) in metabolite identification studies.
• Toxicology & Metabolism Studies: Critical for investigating the metabolic fate and detoxification pathways of chlorinated butadienes and related industrial chemicals.
• Mechanistic Toxicology: Serves as a key intermediate or marker in studies of glutathione S-transferase (GST) enzyme activity and the formation of DNA-reactive species.
• Pharmaceutical Development: Employed in safety assessment (ADME-Tox) to understand and mitigate potential bioactivation risks of drug candidates.
• Analytical Method Development: Used to develop and validate sensitive assays for detecting glutathione-derived conjugates in biological matrices.
• Environmental Health Science: Applied in research assessing human exposure biomarkers to specific environmental pollutants.

Basic Information

Product Name	1,4-(Bis-Glutathion-S-Yl)-1,2,3,4-Tetrachloro-1,3-Butadiene
CAS No.	115664-52-3
Molecular Formula	C₂₀H₃₂Cl₄N₆O₁₂S₂
Molecular Weight	754.52 g/mol
Synonyms	1,4-Bis(glutathion-S-yl)-1,2,3,4-tetrachloro-1,3-butadiene; 1,2,3,4-Tetrachloro-1,4-bis(glutathion-S-yl)butadiene; Glutathione conjugate of tetrachlorobutadiene; Bis-GSH conjugate of 1,2,3,4-Tetrachloro-1,3-butadiene; TCBD-GSH Diconjugate; 1,3-Butadiene, 1,2,3,4-tetrachloro-1,4-bis(glutathion-S-yl)-; (1Z,3Z)-1,2,3,4-Tetrachloro-1,4-bis[(2S)-2-amino-5-[[(1R)-1-[(carboxymethyl)carbamoyl]-2-sulfanylethyl]carbamoyl]pentanamido]buta-1,3-diene
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Quality Control

Our high-value biochemical standards are produced and controlled under a rigorous quality management system. Each batch undergoes comprehensive analytical characterization, including purity assay and structural confirmation, to ensure identity, strength, and composition. Certificates of Analysis (COA) detailing lot-specific results from NMR, MS, and HPLC are provided and traceable to in-house reference standards. We support research requiring cGMP and ISO 17034 compliant reference materials.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under inert atmosphere. The product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms [M-H]- ion
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 3.0 %
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.