Description

5-Deaza-5,6,7,8-Tetrahydrofolic Acid is a specialized folate analog and a key biochemical research compound. This molecule is of significant interest for its role in studying enzyme mechanisms, particularly those involving folate-dependent enzymes, and as a potential tool in metabolic pathway analysis. It is primarily utilized by researchers and developers in the pharmaceutical, biotechnology, and academic sectors for biochemical research, drug discovery, and the development of novel therapeutic agents.

Application

• Biochemical Research: A critical tool for investigating the mechanisms of folate-dependent enzymes, such as dihydrofolate reductase (DHFR) and thymidylate synthase.
• Enzyme Inhibition Studies: Serves as a potential inhibitor or substrate analog in enzymatic assays to understand catalytic pathways and design new inhibitors.
• Drug Discovery & Development: Used in early-stage research for targeting folate metabolism in areas like oncology and antimicrobial therapy.
• Metabolic Pathway Analysis: Employed to study one-carbon metabolism and related biochemical networks in cell culture and model systems.
• Reference Standard: Used as a high-purity analytical standard in method development and quality control for related pharmaceutical compounds.
• Academic Research: Fundamental studies in chemistry and biochemistry to explore structure-activity relationships and novel reaction mechanisms.

Basic Information

Product Name	5-Deaza-5,6,7,8-Tetrahydrofolic Acid
CAS No.	115587-73-0
Molecular Formula	C19H23N7O6
Molecular Weight	445.43 g/mol
Synonyms	5-Deaza-5,6,7,8-tetrahydrofolate; 5-Deaza-THF; NSC 339539; 5-Deaza-5,6,7,8-tetrahydrofolic acid; 5-Deaza-5,6,7,8-tetrahydropteroylglutamic acid; 5-Deaza-tetrahydrofolate; 5-Deaza-5,6,7,8-tetrahydrofolate acid
EINECS	Contact for details

Quality Control

Our 5-Deaza-5,6,7,8-Tetrahydrofolic Acid is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards, and specifications can be tailored to meet specific research-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.