Description

3-Hydroxy-3-Methylglutaric-D3 Anhydride is a deuterated derivative of 3-hydroxy-3-methylglutaric anhydride, a key intermediate in the biosynthesis of isoprenoids and cholesterol. This isotopically labeled compound is essential for metabolic pathway tracing and analytical method development, providing critical insights into biochemical mechanisms. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced chemical synthesis sectors for applications requiring precise isotopic labeling.

Application

• Isotopic Tracer in Metabolic Studies: Used as a deuterium-labeled precursor to investigate the mevalonate pathway and cholesterol biosynthesis in biochemical research.
• Internal Standard for Mass Spectrometry: Serves as a high-purity reference standard in LC-MS and GC-MS analysis for the accurate quantification of related metabolites.
• Advanced Pharmaceutical Intermediate: A key building block in the synthesis of deuterated drug candidates, potentially enhancing metabolic stability and pharmacokinetic profiles.
• Biochemical Research Reagent: Employed in enzymology studies to understand the function of HMG-CoA synthase and related enzymes.
• Stable Isotope Labeling: Facilitates the production of labeled compounds for use in NMR spectroscopy and other analytical techniques.

Basic Information

Product Name	3-Hydroxy-3-Methylglutaric-D3 Anhydride
CAS No.	115135-38-1
Molecular Formula	C6H3D3O4
Molecular Weight	145.13 g/mol
Synonyms	3-Hydroxy-3-methyl[3,4,4-2H3]glutaric Anhydride; HMG-D3 Anhydride; 3-Hydroxy-3-methylglutaric-d3 Anhydride; Deuterated HMG Anhydride; (3R/S)-3-Hydroxy-3-methylpentanedioic-d3 Anhydride; 3-Methyl-3-hydroxyglutaric-d3 Anhydride; 115135-38-1; 3-Hydroxy-3-methylglutaric acid-d3 cyclic anhydride
EINECS	Contact for details

Quality Control

Our 3-Hydroxy-3-Methylglutaric-D3 Anhydride is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including NMR and Mass Spectrometry, to confirm isotopic enrichment, chemical purity, and structural identity. Certificates of Analysis (COA) detailing purity, deuterium content, and impurity profiles are available upon request to support your research and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation by moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Deuterium Content (NMR/MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.