Description

4-Hydroxy Propofol 4-o-B-D-Glucuronide is a major, pharmacologically inactive metabolite of the intravenous anesthetic agent propofol. This compound is of critical importance in pharmaceutical research and development, particularly in the fields of drug metabolism, pharmacokinetics, and bioanalytical method validation. It serves as a key reference standard for laboratories conducting clinical studies, toxicology assessments, and regulatory submissions to ensure accurate quantification of propofol and its metabolites in biological matrices.

Application

• Pharmaceutical Reference Standard: Primary use as a certified reference material (CRM) for the calibration and validation of analytical methods (e.g., LC-MS/MS, HPLC) in bioanalysis.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Essential for investigating the metabolic pathways, clearance rates, and excretion profiles of propofol in preclinical and clinical research.
• Toxicology and Safety Assessment: Used to study the metabolite profile of propofol, supporting safety evaluations and understanding potential drug interactions.
• Clinical Research & Biomarker Development: Facilitates the accurate measurement of propofol metabolite levels in patient samples for therapeutic drug monitoring (TDM) and personalized medicine approaches.
• Regulatory Compliance: Supports the development of data packages for regulatory filings with agencies like the FDA and EMA, ensuring adherence to Good Laboratory Practice (GLP) standards.
• Academic Research: A vital tool for universities and research institutes studying anesthetic mechanisms, metabolic conjugation processes (glucuronidation), and related biochemical pathways.

Basic Information

Product Name	4-Hydroxy Propofol 4-o-B-D-Glucuronide
CAS No.	115005-78-2
Molecular Formula	C24H32O9
Molecular Weight	464.51 g/mol
Synonyms	Propofol 4-O-Glucuronide; 4-Hydroxypropofol 4-O-β-D-Glucuronide; 2,6-Diisopropyl-1,4-benzoquinone 4-O-β-D-Glucuronide (inaccurate but related); Propofol Glucuronide Metabolite; 1-(4-Hydroxy-2,6-diisopropylphenyl)-1-O-β-D-glucopyranuronosyloxyethane; 4'-Hydroxypropofol Glucuronide; Quinone Propofol Glucuronide; 4-OH Propofol Glucuronide
EINECS	Contact for details

Quality Control

Our 4-Hydroxy Propofol 4-o-B-D-Glucuronide is manufactured under controlled conditions to ensure the highest standards of purity and consistency, suitable for sensitive analytical applications. Each batch undergoes rigorous quality testing, including identity confirmation by spectroscopic methods (NMR, IR, MS) and purity assessment by advanced chromatographic techniques (HPLC, UPLC). A comprehensive Certificate of Analysis (COA) is provided, detailing batch-specific results for identity, assay, purity, and related substances. We support compliance with GLP and GMP guidelines for reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay (HPLC)	≥ 98.0% (on dried basis)
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.