Description

Trabectedin CAS NO 114899-77-3 is a potent marine-derived antineoplastic agent belonging to the tetrahydroisoquinoline class. This compound is of critical importance for its unique mechanism of action, which involves binding to the minor groove of DNA and interfering with transcription-coupled nucleotide excision repair. It is primarily required by pharmaceutical manufacturers and advanced research institutions engaged in oncology drug development and clinical studies for the treatment of soft tissue sarcomas and ovarian cancer.

Application

• Oncological Pharmaceutical Manufacturing: Active Pharmaceutical Ingredient (API) for the formulation of injectable chemotherapeutic drugs.
• Clinical Research & Development: Key reference standard and intermediate in preclinical and clinical trials for novel cancer therapies.
• Biochemical Research: Tool compound for studying DNA damage response mechanisms, transcription regulation, and cell cycle arrest in cancer cell lines.
• Anticancer Agent Synthesis: High-purity intermediate for the synthesis of novel tetrahydroisoquinoline alkaloid derivatives and analogs.
• Quality Control & Analytical Standards: Certified reference material for HPLC, LC-MS, and NMR methods in pharmaceutical quality assurance laboratories.

Basic Information

Product Name	Trabectedin
CAS No.	114899-77-3
Molecular Formula	C₃₉H₄₃N₃O₁₁S
Molecular Weight	761.84 g/mol
Synonyms	Ecteinascidin 743; ET-743; Yondelis (trade name); NSC 684766; (1'R,6R,6aR,7R,13S,14S,16R)-6',8,14-Trihydroxy-7',9-dimethoxy-4,10,23-trimethyl-19-oxo-3',4',6,7,12,13,14,16-octahydro-3H-spiro[6,16-(epithiopropanooxymethano)-7,13-imino-12H-1,3-dioxolo[7,8]isoquino[3,2-b][3]benzazocine-20,1'(2'H)-isoquinoline]-6a(2H)-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our Trabectedin is manufactured under strict quality systems to meet the exacting standards of pharmaceutical applications. Each batch is subjected to comprehensive analytical testing including HPLC purity assay, identification by IR and MS, and stringent control of related substances and residual solvents. A Certificate of Analysis (COA) documenting full compliance with in-house specifications is provided with every shipment to ensure traceability and quality assurance for our global B2B clients.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, 15-25°C, or as indicated on the label. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.