Description

(E)-4-Hydroxy-n-Desmethyl Tamoxifen is a key active metabolite of the widely used breast cancer therapeutic, Tamoxifen. This compound is of critical importance in pharmaceutical research and development, particularly for studying drug metabolism, efficacy, and the mechanisms of selective estrogen receptor modulation. It serves as a vital reference standard and analytical standard for laboratories in the pharmaceutical, biotechnology, and clinical diagnostics sectors, enabling precise quantification and validation in bioanalytical studies.

Application

• Pharmaceutical Reference Standard: Primary use as a high-purity certified standard for the quantitative analysis of Tamoxifen and its metabolites in biological matrices.
• Drug Metabolism & Pharmacokinetics (DMPK) Studies: Essential for investigating the metabolic pathways, bioavailability, and clearance of Tamoxifen in preclinical and clinical research.
• Bioanalytical Method Development & Validation: Used to calibrate equipment and validate HPLC, LC-MS/MS, and other analytical methods for accurate therapeutic drug monitoring.
• Clinical Research & Diagnostics: Supports studies on patient response variability, therapeutic drug monitoring, and the development of companion diagnostics.
• Impurity Profiling: Acts as a known impurity standard in the quality control of Tamoxifen active pharmaceutical ingredient (API) manufacturing.
• Academic & Mechanistic Research: Utilized in biochemical assays to study estrogen receptor interactions and the downstream effects of anti-estrogen therapies.

Basic Information

Product Name	(E)-4-Hydroxy-n-Desmethyl Tamoxifen
CAS No.	114828-90-9
Molecular Formula	C25H27NO2
Molecular Weight	373.49 g/mol
Synonyms	4-Hydroxytamoxifen; 4-OHT; Afimoxifene; (Z)-4-Hydroxytamoxifen (Isomer); Endoxifen; Metabolite Y; ICI 79280; FC-1271a; 1-[4-[2-(Dimethylamino)ethoxy]phenyl]-1-(4-hydroxyphenyl)-2-phenylbut-1-ene
EINECS	Contact for details

Quality Control

Every batch of our (E)-4-Hydroxy-n-Desmethyl Tamoxifen is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to support its use as a high-purity reference material. Certificates of Analysis (COA) detailing identity, purity (by HPLC), and impurity profiles are supplied with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This product is light-sensitive and easily oxidized; for long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.