Description

2,2-Difluoro-3-Oxo-3-Phenyl-Propionic Acid Ethyl Ester is a high-value fluorinated building block and a key intermediate in organic synthesis. Its structure, featuring a difluoroacetate moiety adjacent to a benzoyl group, makes it a versatile precursor for the development of pharmaceuticals and advanced materials. This compound is primarily sought by research and development chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing difluoromethyl or trifluoromethyl groups.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides where fluorine substitution enhances biological activity and stability.
• Fluorinated Material Precursor: Serves as a monomer or intermediate for creating specialty polymers, liquid crystals, and electronic materials with unique properties.
• Organic Synthesis Reagent: Employed in various name reactions and methodologies, such as Reformatsky-type reactions or nucleophilic additions, to introduce fluorinated carbonyl units.
• Research & Development: Essential for medicinal chemistry programs and process chemistry optimization in both academic and industrial R&D laboratories.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke fluorinated compounds for clients.

Basic Information

Product Name	2,2-Difluoro-3-Oxo-3-Phenyl-Propionic Acid Ethyl Ester
CAS No.	114701-62-1
Molecular Formula	C11H10F2O3
Molecular Weight	228.19 g/mol
Synonyms	Ethyl 2,2-Difluoro-3-oxo-3-phenylpropanoate; Ethyl 2,2-Difluoro-3-oxo-3-phenylpropionate; 3-Phenyl-2,2-difluoromalonic Acid Monoethyl Ester; Ethyl (Difluorobenzoyl)acetate; DFPPE; 114701-62-1; Ethyl 2,2-Difluoro-3-oxo-3-phenylpropanoate
EINECS	Contact for details

Quality Control

Our 2,2-Difluoro-3-Oxo-3-Phenyl-Propionic Acid Ethyl Ester is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from strong bases, strong oxidizing agents, and sources of ignition. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥97.0% (Standard Grade)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.