Description

(-)-trans-(1S,2S)-U-50488 Hydrochloride is a potent and selective agonist for the kappa opioid receptor (KOR), widely recognized as a critical pharmacological tool in neuroscience research. Its high selectivity makes it invaluable for studying the complex physiological and behavioral effects mediated by the kappa opioid system. This compound is essential for researchers and pharmaceutical developers in neuropharmacology, pain management research, and the development of novel central nervous system (CNS) therapeutics.

Application

• Neuroscience Research: A primary reference standard for investigating kappa opioid receptor (KOR) signaling pathways, receptor binding affinity, and functional activity in vitro and in vivo.
• Pharmacological Studies: Used to elucidate the role of KOR in pain modulation, mood disorders, addiction, and stress responses, serving as a key comparator in drug discovery programs.
• Biochemical Assay Development: Employed as a control compound in high-throughput screening (HTS) assays and functional tests (e.g., cAMP inhibition, β-arrestin recruitment) to validate assay performance for KOR-targeted compounds.
• Reference Standard: Serves as a certified analytical standard for the quantification and purity assessment of U-50488 derivatives in research samples and pharmaceutical quality control (QC) laboratories.
• Academic & Institutional Research: Fundamental for university and institutional labs conducting basic research on opioid receptor subtypes and their physiological roles.

Basic Information

Product Name	(-)-trans-(1S,2S)-U-50488 Hydrochloride
CAS No.	114528-79-9
Molecular Formula	C19H28ClNO2
Molecular Weight	337.89 g/mol
Synonyms	(1S,2S)-U-50488 Hydrochloride; (1S,2S)-U-50488 HCl; (-)-U-50488 Hydrochloride; trans-(1S,2S)-U-50488 Hydrochloride; (1S,2S)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide Hydrochloride; U-50488 Hydrochloride (enantiomer); Kappa Opioid Receptor Agonist U-50488; KOR Agonist U-50488
EINECS	Contact for details

Quality Control

Our (-)-trans-(1S,2S)-U-50488 Hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation via spectroscopic methods, and impurity profiles. We adhere to rigorous analytical standards to meet the exacting requirements of pharmaceutical and life science research.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.