Description

3-Bromo-5-(Difluoromethyl)Pyridine, 97% is a high-purity halogenated pyridine derivative serving as a versatile and critical building block in advanced organic synthesis. Its value lies in the strategic placement of bromine and difluoromethyl groups on the pyridine ring, enabling precise functionalization for creating complex molecular architectures. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting kinase inhibitors and central nervous system (CNS) agents.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the bioactivity of the difluoromethylpyridine moiety.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands used in catalysis and material science applications.
• Functional Material Research: Employed in the synthesis of organic electronic materials, such as those used in OLEDs or conductive polymers, due to its electron-deficient pyridine core.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi, Stille) to form biaryl and other complex structures.
• Fluorine Chemistry Building Block: The difluoromethyl group provides a valuable source of fluorine for probing structure-activity relationships (SAR) in drug discovery.

Basic Information

Product Name	3-Bromo-5-(Difluoromethyl)Pyridine, 97%
CAS No.	114468-04-1
Molecular Formula	C6H4BrF2N
Molecular Weight	208.00 g/mol
Synonyms	5-(Difluoromethyl)-3-bromopyridine; 3-Bromo-5-difluoromethylpyridine; Pyridine, 3-bromo-5-(difluoromethyl)-; 114468-04-1; 3-Bromo-5-(difluoromethyl)pyridin; 3-Br-5-CF2H-Pyridine
EINECS	Contact for details

Quality Control

Every batch of 3-Bromo-5-(Difluoromethyl)Pyridine is manufactured and tested under a strict quality management system. Our products undergo rigorous quality testing, including chromatographic purity analysis and identity confirmation, to ensure compliance with industry standards and customer specifications. Certificates of Analysis (COA) documenting batch-specific results are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.