Description

Methylglyoxal Bis(Cyclohexylamidinohydrazone) is a specialized chemical compound with significant utility in advanced research and industrial synthesis. Its primary value lies in its role as a potent and selective inhibitor of the glyoxalase system, making it a critical research tool for studying cellular metabolism and stress response pathways. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors, particularly those focused on oncology, metabolic disorders, and enzyme mechanism studies.

Application

• Biochemical Research: A key inhibitor for studying the glyoxalase I (GLO1) enzyme pathway, which is implicated in diabetic complications, cancer, and neurological disorders.
• Pharmaceutical Development: Used as a reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel therapeutic agents targeting methylglyoxal detoxification pathways.
• Enzymology Studies: Employed in in vitro and cell-based assays to investigate enzyme kinetics, inhibition mechanisms, and cellular response to dicarbonyl stress.
• Metabolic Pathway Analysis: Facilitates research into advanced glycation end-products (AGEs) formation and related metabolic processes.
• Academic Research: Utilized in university and institutional laboratories for fundamental research in biochemistry, molecular biology, and medicinal chemistry.

Basic Information

Product Name	Methylglyoxal Bis(Cyclohexylamidinohydrazone)
CAS No.	114319-00-5
Molecular Formula	C₁₆H₂₈N₆O₂
Molecular Weight	336.44 g/mol
Synonyms	Methylglyoxal bis(cyclohexylamidinohydrazone); GLO1 Inhibitor; Glyoxalase I Inhibitor; Methylglyoxal bis(cyclohexylguanidinohydrazone); CAS 114319-00-5; 1,1'-[1-Methyl-1,2-ethanediylidene]bis[2-(cyclohexylamino)hydrazine]; pGSC (potential Glyoxalase System Compound); MGBCH
EINECS	Contact for details

Quality Control

Our Methylglyoxal Bis(Cyclohexylamidinohydrazone) is produced under stringent quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. Return the container to storage immediately after use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.