Description

Cyclopropylmethanesulfonyl Chloride is a specialized organosulfur reagent featuring a reactive sulfonyl chloride group attached to a cyclopropylmethyl scaffold. This compound is a critical building block in modern synthetic chemistry, enabling the efficient introduction of the cyclopropylmethylsulfonyl moiety into target molecules. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of sulfonamide-based drug candidates, including protease inhibitors and kinase modulators.
• Agrochemical Synthesis: Used in the development of novel herbicides and fungicides where the cyclopropyl group confers specific biological activity.
• Chemical Biology Probes: Serves as a reactive handle for labeling proteins or modifying biomolecules in probe development.
• Material Science Research: Employed in the synthesis of functional monomers or polymers with tailored properties.
• Cross-Coupling Reactions: Acts as an electrophile in metal-catalyzed cross-coupling reactions to form carbon-sulfur bonds.
• Sulfonylation Agent: Used to sulfonylate amines, alcohols, and other nucleophiles to create sulfonamides and sulfonate esters.

Basic Information

Product Name	Cyclopropylmethanesulfonyl Chloride
CAS No.	114132-26-2
Molecular Formula	C4H7ClO2S
Molecular Weight	154.61 g/mol
Synonyms	Cyclopropylmethylsulfonyl chloride; (Cyclopropylmethyl)sulfonyl chloride; Cyclopropanemethanesulfonyl chloride; Cyclopropylmethanesulfonic acid chloride; Cyclopropylmethyl sulfone chloride; CPMS-Cl; 114132-26-2
EINECS	Contact for details

Quality Control

Our Cyclopropylmethanesulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.