Description

Z-Phe-Tyr(Tbu)-Diazomethylketone is a specialized, high-purity peptide derivative designed for advanced research and development. This compound serves as a critical building block and a potent, irreversible inhibitor of specific proteases, particularly cysteine proteases like cathepsins. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who are developing novel therapeutic agents, diagnostic tools, and biochemical probes. The product is supplied with a focus on batch-to-batch consistency and reliable performance in sensitive applications.

Application

• Protease Inhibition Research: Acts as a potent, irreversible active-site directed inhibitor for mechanistic studies of cysteine proteases, including cathepsin L and related enzymes.
• Pharmaceutical Development: Used as a key intermediate or pharmacological tool compound in the discovery and development of drugs targeting protease-mediated diseases such as cancer, osteoporosis, and parasitic infections.
• Biochemical Probe Synthesis: Serves as a precursor for creating affinity labels, activity-based probes (ABPs), and bioconjugates for proteomics and enzyme profiling.
• Peptide Chemistry: Employed in solid-phase and solution-phase peptide synthesis as a protected dipeptide derivative for constructing more complex peptide sequences.
• Academic & Industrial R&D: A vital reagent for fundamental biochemical research in universities, government labs, and contract research organizations (CROs).

Basic Information

Product Name	Z-Phe-Tyr(Tbu)-Diazomethylketone
CAS No.	114014-15-2
Molecular Formula	C31H40N4O6
Molecular Weight	564.68 g/mol
Synonyms	Z-Phe-Tyr(tBu)-CHN2; Benzyloxycarbonyl-Phenylalanyl-O-tert-butyl-Tyrosyl Diazomethyl Ketone; Z-Phe-Tyr(tBu)-Diazomethane; Cbz-Phe-Tyr(tBu)-CHN2; Cathepsin L Inhibitor IV (Z-Phe-Tyr(tBu)-diazomethylketone); (2S)-2-[[(2S)-2-[[(2S)-3-Phenyl-2-(phenylmethoxycarbonylamino)propanoyl]amino]-3-[4-[(2-methylpropan-2-yl)oxy]phenyl]propanoyl]amino]acetic acid diazomethyl ketone
EINECS	Contact for details

Quality Control

Our Z-Phe-Tyr(Tbu)-Diazomethylketone is manufactured under controlled conditions to ensure the highest standards of purity and identity. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment, NMR and MS for structural confirmation, and chiral analysis to verify enantiomeric purity. Certificates of Analysis (COA) detailing all specifications and test results are provided to guarantee traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in alcohols

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.