Description

Phaclofen is a potent and selective antagonist for the GABAB receptor subtype, a key target in neuropharmacological research. This high-purity compound is essential for elucidating the role of GABAB receptors in neurological pathways and their potential therapeutic applications. It is primarily utilized by research institutions and pharmaceutical R&D departments focused on neuroscience, neuropathic pain, and central nervous system disorders.

Application

• Neuroscience Research: A critical tool for studying GABAB receptor function, synaptic transmission, and neuronal excitability in vitro and in vivo.
• Pharmacological Studies: Used to investigate receptor mechanisms, dose-response relationships, and the effects of GABAergic signaling in experimental models.
• Target Validation: Employed in drug discovery programs to validate the GABAB receptor as a target for new therapeutic agents.
• Academic & Institutional R&D: Serves as a standard reference compound in university laboratories and research institutes worldwide.

Basic Information

Product Name	Phaclofen
CAS No.	114012-12-3
Molecular Formula	C10H12ClNO4P
Molecular Weight	291.63 g/mol
Synonyms	(3-Amino-2-(4-chlorophenyl)propyl)phosphinic acid; (R,S)-Phaclofen; GABAB receptor antagonist; 3-Amino-2-(p-chlorophenyl)propylphosphinic acid; p-Chlorophenyl-β-aminopropylphosphinic acid; β-(p-Chlorophenyl)-γ-aminopropylphosphinic acid; Phaclofen (GABAB antagonist)
EINECS	Contact for details

Quality Control

Our Phaclofen is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with our stringent in-house specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at -20°C under desiccant.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.