Description

Bisindolylmaleimide V CAS NO 113963-68-1 is a potent and selective cell-permeable inhibitor of protein kinase C (PKC) isoforms. This compound is a critical research tool for elucidating the complex signaling pathways involved in cellular regulation, proliferation, and apoptosis. It is primarily utilized by researchers and scientists in the fields of biochemistry, pharmacology, and oncology for in vitro and in vivo studies.

Application

• Biochemical Research: A key tool for studying PKC-mediated signal transduction pathways and enzyme kinetics.
• Pharmacological Studies: Used to investigate the role of PKC in disease models, aiding in the discovery and validation of novel therapeutic targets.
• Cancer Research: Employed to probe the involvement of specific PKC isoforms in tumor cell growth, survival, and metastasis.
• Neuroscience: Applied in research on PKC's function in neuronal plasticity, neurotransmitter release, and neurodegenerative conditions.
• Cardiovascular Research: Utilized to explore PKC signaling in cardiac hypertrophy, vascular tone, and heart failure.
• Inflammatory Disease Models: Serves as a reference inhibitor to understand PKC's role in immune cell activation and inflammatory responses.

Basic Information

Product Name	Bisindolylmaleimide V
CAS No.	113963-68-1
Molecular Formula	C₂₃H₂₀N₄O₂
Molecular Weight	384.43 g/mol
Synonyms	BIM-V; 3-[1-[3-(Dimethylamino)propyl]-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione; GF 109203X; Go 6850; Protein Kinase C Inhibitor, Bisindolylmaleimide V; PKC Inhibitor V
EINECS	Contact for details

Quality Control

Our Bisindolylmaleimide V is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and structural identity. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided to guarantee batch-to-batch consistency for your research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. The product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to warm to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.