Description

1-Monomethylphosphoinositol 4,5-Bisphosphate is a specialized, high-purity phosphatidylinositol phosphate (PIP) derivative, a key signaling molecule in cellular biochemistry. This compound is essential for research into intracellular signal transduction pathways, particularly those involving phospholipase C and phosphoinositide 3-kinase (PI3K). It is primarily utilized by biochemical researchers, pharmaceutical R&D teams, and diagnostic manufacturers for studying cell membrane dynamics, enzyme kinetics, and developing targeted therapeutics.

Application

• Biochemical Research: As a critical substrate or standard in studies of phosphoinositide-specific phospholipase C (PI-PLC) and other lipid-modifying enzymes.
• Cell Signaling Studies: Investigating the role of phosphatidylinositol phosphates in cellular processes like vesicle trafficking, cytoskeletal organization, and apoptosis.
• Pharmaceutical Development: Serving as a reference compound or tool molecule in drug discovery programs targeting lipid signaling pathways for oncology, metabolic, and neurological disorders.
• Diagnostic Assay Development: Used in the production of kits and reagents for measuring enzyme activity or detecting specific lipid metabolites.
• Enzyme Kinetics & Characterization: Providing a defined substrate for determining kinetic parameters (Km, Vmax) of lipid kinases and phosphatases.
• Academic & Institutional Research: Fundamental research in molecular biology, cell biology, and biochemistry laboratories worldwide.

Basic Information

Product Name	1-Monomethylphosphoinositol 4,5-Bisphosphate
CAS No.	113872-20-1
Molecular Formula	C7H15O18P3
Molecular Weight	504.09 g/mol
Synonyms	PtdIns(4,5)P2 Methyl Ester; 1-Monomethyl PtdIns(4,5)P2; Methyl Phosphatidylinositol 4,5-Bisphosphate; PI(4,5)P2 Methyl Ester; 1-Monomethylphosphatidylinositol 4,5-bisphosphate; 1-Methyl-PIP2; D-myo-Inositol 1-(methyl phosphate), 4,5-bis(dihydrogen phosphate)
EINECS	Contact for details

Quality Control

Our 1-Monomethylphosphoinositol 4,5-Bisphosphate is produced under stringent quality management systems to ensure batch-to-batch consistency and high purity for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to ISO 9001 standards, and our quality protocols are designed to meet the rigorous demands of pharmaceutical and academic research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, consider under an inert atmosphere. Allow the product to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in chloroform/methanol/water mixtures

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.