Description

3-Fluoro-4-(trifluoromethyl)pyridine is a versatile fluorinated pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both fluorine and a trifluoromethyl group on the pyridine ring, imparts significant electronic and steric properties, making it invaluable for modulating the activity and physicochemical profile of target molecules. This high-value intermediate is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and central nervous system (CNS) targeted drugs.
• Agrochemical Synthesis: Used in the research and production of modern herbicides, fungicides, and insecticides, where the fluorine atoms enhance bioavailability and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of fluorinated polymers, liquid crystals, and electronic materials for their unique dielectric and surface properties.
• Chemical Biology & Proteomics: Useful as a tagging or probing agent due to the distinct properties of the fluorine atom for NMR studies.
• Custom Synthesis and R&D: A fundamental starting material for contract research organizations (CROs) and fine chemical companies engaged in custom synthesis projects.

Basic Information

Product Name	3-Fluoro-4-(trifluoromethyl)pyridine
CAS No.	113770-87-9
Molecular Formula	C6H3F4N
Molecular Weight	165.09 g/mol
Synonyms	4-(Trifluoromethyl)-3-fluoropyridine; 3-Fluoro-4-trifluoromethylpyridine; Pyridine, 3-fluoro-4-(trifluoromethyl)-; 3-Fluoro-4-(trifluoromethyl)pyridine; 3-Fluoro-4-(trifluoromethyl)pyridine (9CI)
EINECS	Contact for details

Quality Control

Our 3-Fluoro-4-(trifluoromethyl)pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use. Keep away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.