Description

Nf-Kb Activation Inhibitor Vi, Bot-64 CAS NO 113760-29-5 is a potent and selective small-molecule inhibitor that targets the NF-κB signaling pathway, a critical regulator of immune and inflammatory responses. This compound is essential for researchers and developers in the life sciences sector, providing a reliable tool for modulating cellular processes linked to inflammation, immunity, and cell survival. It is primarily utilized in pharmaceutical R&D, academic research, and biotechnology for investigating disease mechanisms and developing novel therapeutic agents.

Application

• Biomedical Research: A key reagent for studying the molecular mechanisms of the NF-κB pathway in cellular models of inflammation and immunity.
• Drug Discovery & Development: Used as a reference standard and pharmacological tool in high-throughput screening and lead optimization for anti-inflammatory and anti-cancer therapeutics.
• Academic Studies: Facilitates fundamental research in immunology, oncology, and neurobiology to elucidate disease pathways and identify new drug targets.
• Preclinical Testing: Employed in in vitro and in vivo studies to validate the efficacy of pathway inhibition and assess potential therapeutic effects.
• Biochemical Assay Development: Serves as a critical control compound in developing and validating assays that measure NF-κB activation and related cellular responses.

Basic Information

Product Name	Nf-Kb Activation Inhibitor Vi, Bot-64
CAS No.	113760-29-5
Molecular Formula	C17H14N4O2S
Molecular Weight	338.38 g/mol
Synonyms	BAY 11-7082; BAY 11-7085; (E)-3-(4-Methylphenylsulfonyl)-2-propenenitrile; BAY11-7082; NF-κB Activation Inhibitor; IKK-2 Inhibitor VI; BAY11-7085; NFκB Activation Inhibitor
EINECS	Contact for details

Quality Control

Our Nf-Kb Activation Inhibitor Vi, Bot-64 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for research chemicals, and custom purity grades or analytical services are available to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure the container is sealed tightly after each use to minimize exposure to moisture and light. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	<10 ppm
Solubility	Soluble in DMSO, DMF; slightly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.