Description

Inositol 1,4,5-Triphosphorothioate is a chemically modified analog of the critical second messenger inositol 1,4,5-trisphosphate (IP3), where one or more of the phosphate oxygen atoms is replaced by sulfur. This compound is a vital research tool for investigating calcium signaling pathways, offering enhanced resistance to enzymatic hydrolysis. It is primarily utilized by researchers and developers in pharmaceutical discovery, biochemical research, and cell biology to study receptor interactions and develop novel therapeutic agents targeting intracellular signaling.

Application

• Biochemical Research: As a hydrolysis-resistant analog to probe the structure and function of IP3 receptors (IP3R) in calcium (Ca²⁺) release from endoplasmic reticulum stores.
• Pharmaceutical Development: A key tool in high-throughput screening assays to identify and characterize potential modulators (agonists/antagonists) of the IP3 signaling pathway for drug discovery.
• Cell Signaling Studies: Used to elucidate the precise mechanisms of G-protein coupled receptor (GPCR) mediated signaling and downstream cellular responses.
• Enzymology: Serves as a substrate analog to study the specificity and kinetics of phosphatases and kinases involved in inositol phosphate metabolism.
• Neuroscience Research: Investigates the role of IP3-mediated calcium signaling in neuronal function, synaptic plasticity, and related neurological disorders.

Basic Information

Product Name	Inositol 1,4,5-Triphosphorothioate
CAS No.	113596-09-1
Molecular Formula	C6H15O15P3S
Molecular Weight	506.15 g/mol
Synonyms	IP3S; D-myo-Inositol 1,4,5-Trisphosphorothioate; 1,4,5-IP3S; myo-Inositol 1,4,5-trisphosphorothioate; Inositol 1,4,5-trisphosphorothioic acid; Ins(1,4,5)PS3; Adenophostin A analog; Calcium signaling agent
EINECS	Contact for details

Quality Control

Every batch of Inositol 1,4,5-Triphosphorothioate is produced and analyzed under strict quality protocols to ensure high purity and batch-to-batch consistency for research applications. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is available upon request to support your research and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in water or aqueous buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.