Description

2,6-Dichloro-5-Fluoronicotinamide is a high-purity fluorinated pyridine derivative, serving as a critical advanced pharmaceutical intermediate (API intermediate). Its value lies in enabling the synthesis of complex, bioactive molecules, particularly in the development of novel agrochemicals and active pharmaceutical ingredients (APIs). This compound is essential for R&D and production teams in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate a fluorinated nicotinamide scaffold into their target compounds.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders, anti-infectives, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and insecticides, where the fluorine atom enhances biological activity and environmental stability.
• Chemical Research & Development: Serves as a versatile precursor in organic synthesis for creating novel fluorinated heterocyclic compounds in academic and industrial R&D settings.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for metal-catalyzed cross-coupling reactions, which are fundamental to modern fine chemical manufacturing.

Basic Information

Product Name	2,6-Dichloro-5-Fluoronicotinamide
CAS No.	113237-20-0
Molecular Formula	C6H3Cl2FN2O
Molecular Weight	209.00 g/mol
Synonyms	5-Fluoro-2,6-dichloronicotinamide; 2,6-Dichloro-5-fluoropyridine-3-carboxamide; 3-Carbamoyl-2,6-dichloro-5-fluoropyridine; 113237-20-0; 5-Fluoro-2,6-dichloro-3-pyridinecarboxamide; 2,6-Dichloro-5-fluoro-3-pyridinecarboxamide; 2,6-Dichloro-5-fluoronicotinic acid amide
EINECS	Contact for details

Quality Control

Our 2,6-Dichloro-5-Fluoronicotinamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets exacting standards for use as a pharmaceutical intermediate. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.