Description

D-Buthionine-(S,R)-Sulfoximine is a potent and selective inhibitor of γ-glutamylcysteine synthetase, a key enzyme in the glutathione biosynthesis pathway. This compound is a critical research tool for studying oxidative stress, cellular detoxification mechanisms, and the role of glutathione in various physiological and pathological processes. It is essential for researchers and developers in the fields of pharmaceutical R&D, oncology, neurobiology, and toxicology who require high-purity biochemical reagents for mechanistic studies and drug discovery.

Application

• Biochemical Research: Used as a specific inhibitor to deplete intracellular glutathione levels in cell culture and animal models.
• Cancer Research: Investigated for its potential to sensitize tumor cells to chemotherapy and radiation therapy by inhibiting glutathione synthesis.
• Neurodegenerative Disease Studies: Applied in research models for Parkinson's, Alzheimer's, and other diseases to study the impact of oxidative stress.
• Toxicology & Pharmacology: Employed to understand drug metabolism, hepatotoxicity, and the body's defense mechanisms against xenobiotics.
• Apoptosis & Cell Death Research: Utilized to explore the relationship between redox balance and programmed cell death pathways.
• Agricultural Chemical Research: Potential use in studying plant stress responses and developing novel agrochemicals.

Basic Information

Product Name	D-Buthionine-(S,R)-Sulfoximine
CAS No.	113158-69-3
Molecular Formula	C8H18N2O3S
Molecular Weight	222.30 g/mol
Synonyms	D-BSO; (2R)-2-Amino-4-[(S)-{[(R)-butylsulfinyl]imino}methyl]butanoic Acid; Buthionine Sulfoximine (D-isomer); L-Buthionine-(S,R)-sulfoximine enantiomer; γ-Glutamylcysteine Synthetase Inhibitor; GCS Inhibitor; BSO (D-form)
EINECS	Contact for details

Quality Control

Our D-Buthionine-(S,R)-Sulfoximine is produced under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to rigorous analytical standards utilizing techniques such as HPLC, NMR, and mass spectrometry to verify product integrity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.