Description

Norbinaltorphimine Dihydrochloride is a potent and highly selective κ-opioid receptor (KOR) antagonist. This compound is a critical research tool for neuropharmacological studies, enabling the precise investigation of the κ-opioid system's role in pain, addiction, and mood disorders. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and contract research organizations (CROs) focused on central nervous system (CNS) drug discovery and neurobiological research.

Application

• Neuropharmacological Research: A standard tool for studying the physiological and behavioral effects mediated by κ-opioid receptors.
• Drug Discovery & Development: Used in high-throughput screening (HTS) and lead optimization for novel analgesics and psychotherapeutics targeting the KOR.
• Preclinical Studies: Employed in animal models to validate the role of KOR in pain modulation, stress responses, and reward pathways.
• Biochemical Assays: Serves as a reference standard in receptor binding and functional assays (e.g., GTPγS) to determine compound affinity and efficacy.
• Academic Research: Fundamental for university labs exploring opioid receptor subtypes, signal transduction mechanisms, and neurochemical pathways.
• Toxicology & Safety Pharmacology: Used to assess off-target effects and understand the safety profile of new chemical entities interacting with the opioid system.

Basic Information

Product Name	Norbinaltorphimine Dihydrochloride
CAS No.	113158-34-2
Molecular Formula	C₂₉H₃₄Cl₂N₂O₄
Molecular Weight	545.50 g/mol
Synonyms	Nor-BNI dihydrochloride; Norbinaltorphimine 2HCl; 17,17'-Bis(cyclopropylmethyl)-6,6',7,7'-tetradehydro-4,5α:4',5'α-diepoxy-3,3'-dihydroxy-6,6'-dimethyl-6,6'-bis(2-[3-furyl]ethyl)[2,2'-binorphinan]-7,7'-diol dihydrochloride; Nor-Binaltorphimine dihydrochloride; Norbinaltorphimine HCl; Nor-BNI; (5α,7α,8β)-N-Methyl-N-[7-(1-pyrrolidinyl)-1-oxaspiro[4.5]dec-8-yl]-4-benzofuranacetamide dihydrochloride (related structure); κ-opioid receptor antagonist Nor-BNI.
EINECS	Contact for details

Quality Control

Our Norbinaltorphimine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided, confirming identity, purity, and strength. We support research with materials that meet the stringent requirements for pharmacological reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	<20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.