Description

7-Ethyl-10-Hydroxycamptothecin is a potent topoisomerase I inhibitor and a key synthetic derivative of the natural product camptothecin. This compound is of significant commercial and research interest due to its role as a critical intermediate in the synthesis of advanced anticancer agents. It is primarily required by pharmaceutical R&D laboratories and manufacturers engaged in the development and production of novel chemotherapeutic drugs.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of potent anticancer drugs, including irinotecan (CPT-11) and other camptothecin analogs.
• Oncology Research: Used as a reference standard and active compound in biochemical and pharmacological studies targeting topoisomerase I.
• Drug Discovery & Development: Serves as a core scaffold for medicinal chemistry programs aimed at creating new chemotherapeutic entities with improved efficacy and reduced toxicity.
• Active Pharmaceutical Ingredient (API) Manufacturing: Employed in the controlled synthesis of final drug substances for clinical and commercial use.
• Biochemical Reagent: Utilized in *in vitro* assays to study DNA replication, cell cycle arrest, and apoptosis mechanisms.

Basic Information

Product Name	7-Ethyl-10-Hydroxycamptothecin
CAS No.	113015-38-6
Molecular Formula	C22H20N2O5
Molecular Weight	392.41 g/mol
Synonyms	SN-38; 10-Hydroxy-7-ethylcamptothecin; 7-Ethyl-10-hydroxycamptothecin; (S)-10-Hydroxy-7-ethylcamptothecin; 7-Ethyl-10-hydroxy-(20S)-camptothecin; Irinotecan metabolite; CPT-11 active metabolite; NSC 669123
EINECS	Contact for details

Quality Control

Our 7-Ethyl-10-Hydroxycamptothecin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical intermediate use. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. This product is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Yellow to light yellow powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.2%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.