Description

1-Keto Bambuterol is a key pharmaceutical intermediate and a primary metabolite of the bronchodilator Bambuterol. This compound is of significant importance for the development and quality control of respiratory medications, ensuring precise pharmacological activity and metabolic profiling. It is primarily required by pharmaceutical R&D laboratories, analytical testing facilities, and manufacturers of active pharmaceutical ingredients (APIs) for the production of advanced asthma and chronic obstructive pulmonary disease (COPD) therapeutics.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of the bronchodilator Bambuterol hydrochloride and related therapeutic agents.
• Reference Standard: Used as a high-purity chemical standard in analytical laboratories for method development, validation, and quality control testing of drug substances and products.
• Metabolite Studies: Employed in pharmacokinetic and pharmacodynamic research to study the metabolism, bioavailability, and biological activity of Bambuterol.
• Impurity Profiling: Essential for identifying and quantifying related substances and degradation products during API manufacturing to ensure final product purity and safety.
• Research & Development: Serves as a building block in medicinal chemistry for the design and synthesis of novel β-2 adrenergic receptor agonists.

Basic Information

Product Name	1-Keto Bambuterol
CAS No.	112935-94-1
Molecular Formula	C₁₈H₂₉N₃O₅
Molecular Weight	367.44 g/mol
Synonyms	Bambuterol Impurity F; Bambuterol Metabolite; 5-[2-[(1,1-Dimethylethyl)amino]-1-hydroxyethyl]-1,3-phenylene bis(dimethylcarbamate); 1,3-Bis[(dimethylamino)carbonyl]-5-[2-[(1,1-dimethylethyl)amino]-1-hydroxyethyl]benzene; Bambuterol Related Compound F; Bambuterol Ketone
EINECS	Contact for details

Quality Control

Our 1-Keto Bambuterol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.