Description

3-Fluoro-4-Methoxyphenylmagnesium Bromide is a versatile organometallic reagent, specifically a Grignard reagent, widely used in advanced organic synthesis. Its core value lies in its ability to introduce the 3-fluoro-4-methoxyphenyl moiety, a valuable structural motif, into complex molecules through carbon-carbon bond formation. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries who require high-purity, reliable building blocks for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key building block for synthesizing active pharmaceutical ingredients (APIs) containing fluorinated aryl ether structures, which are common in CNS, anti-inflammatory, and anticancer drug candidates.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where the fluorine and methoxy substituents enhance biological activity and environmental stability.
• Liquid Crystal & OLED Material Precursor: Serves as a critical reagent for constructing fluorinated aromatic cores in electronic and photonic materials for displays and lighting.
• Cross-Coupling Reactions: Employed in Kumada, Negishi, and other transition-metal catalyzed cross-coupling reactions to create complex biaryl systems.
• Nucleophilic Addition Reactions: Reacts with a wide range of electrophiles including carbonyl compounds (aldehydes, ketones, esters), epoxides, and carbon dioxide to form new C-C bonds.
• Custom Chemical & Contract Research: An essential tool for custom synthesis and research organizations developing proprietary compounds for clients.

Basic Information

Product Name	3-Fluoro-4-Methoxyphenylmagnesium Bromide
CAS No.	112780-67-3
Molecular Formula	C7H6FOMgBr
Molecular Weight	229.33 g/mol
Synonyms	(3-Fluoro-4-methoxyphenyl)magnesium bromide; Magnesium, bromo(3-fluoro-4-methoxyphenyl)-; 3-Fluoro-4-methoxybenzene, bromomagnesio-; 3-Fluoro-4-methoxyphenyl Grignard reagent; 3-Fluoro-4-methoxybenzylmagnesium bromide (common misnomer); 3-Fluoro-p-anisylmagnesium bromide; 4-Methoxy-3-fluorophenylmagnesium bromide; F,MeO-PhMgBr
EINECS	Contact for details

Quality Control

Our 3-Fluoro-4-Methoxyphenylmagnesium Bromide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high reactivity. Each lot is analyzed to confirm identity, concentration, and suitability for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing concentration (typically supplied as a solution in THF or diethyl ether), titration results, and impurity profile is provided with every shipment. We adhere to cGMP principles where applicable to support our customers in regulated development pipelines.

Storage

Preserve in a tightly closed container, protected from light. This product is hygroscopic (moisture-sensitive) and must be stored under an inert atmosphere (argon or nitrogen) to prevent decomposition. For solutions, store at 2-8°C in a dedicated flammable materials refrigerator. Keep away from heat, sparks, open flames, and strong oxidizers. Use appropriate grounding and bonding procedures during handling to avoid static discharge.

Specification

Item	Specification
Appearance (Solution)	Clear, colorless to light yellow or brown solution
Concentration	Typically 0.5 M to 2.0 M in THF or Diethyl Ether
Assay (Titration)	≥ 95% of stated concentration
Identity (IR / NMR)	Conforms to reference spectrum
Water Content (Karl Fischer)	< 100 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.