Description

3-(4-Azido-3-Iodophenyl)Propionamide-4-(4,6-Dideoxyglucosyl)Digitoxigenin is a sophisticated synthetic derivative of digitoxigenin, a key aglycone of cardiac glycosides, modified with a photoactivatable azido group and a sugar moiety. This compound is engineered for advanced research applications, particularly in the development of targeted probes and conjugates for biochemical studies. It is primarily utilized by pharmaceutical R&D teams and academic researchers focused on cardiology, molecular biology, and photochemistry.

Application

• Photocrosslinking Agent: The aryl azide group serves as a photoaffinity label for studying protein-ligand interactions and receptor mapping.
• Cardiac Glycoside Research: Acts as a crucial intermediate or probe in the study of Na+/K+-ATPase inhibition and related cardiac mechanisms.
• Bioconjugation & Probe Synthesis: Used to create fluorescent, radioactive, or affinity-tagged derivatives for cellular imaging and target identification.
• Medicinal Chemistry: Serves as a building block for synthesizing novel analogs with potential therapeutic activity for heart failure and arrhythmias.
• Biochemical Tool Development: Employed in the design of activity-based probes to investigate the distribution and function of digitalis receptors.

Basic Information

Product Name	3-(4-Azido-3-Iodophenyl)Propionamide-4-(4,6-Dideoxyglucosyl)Digitoxigenin
CAS No.	112761-66-7
Molecular Formula	C35H45IN4O8
Molecular Weight	800.67 g/mol
Synonyms	Digitoxigenin 3-(4-azido-3-iodobenzoyl)propionamide 4-(4,6-dideoxyglucoside); 4'-Azido-3'-iodo-digitoxigenin benzoylpropionamide glucoside; 3-(4-Azido-3-iodobenzamido)propionyl-digitoxigenin glucoside; Azido-iodo-digitoxigenin probe; Photoactivatable digitoxigenin derivative; Cardiac glycoside photoaffinity label; N-[3-(4-Azido-3-iodophenyl)propanoyl]-4-(4,6-dideoxy-β-D-glucopyranosyl)digitoxigenin
EINECS	Contact for details

Quality Control

This high-purity research chemical is produced under strict quality control protocols. Each batch is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to ensure structural identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profile is provided with every shipment to support your critical research and development work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This compound is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider desiccation and under inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.