Description

U-73122 is a potent and selective cell-permeable inhibitor of phospholipase C (PLC), a key enzyme in intracellular signal transduction pathways. This compound is a critical research tool for elucidating the role of PLC in cellular processes such as calcium mobilization, secretion, and proliferation. It is primarily utilized by researchers in the fields of biochemistry, pharmacology, and cell biology. The product, identified by CAS No. 112648-68-7, is supplied with guaranteed high purity to ensure reliable and reproducible experimental results.

Application

U-73122 is a specialized biochemical reagent with applications in advanced life science research and development.

• Mechanistic Studies: Used to investigate phospholipase C (PLC)-dependent signaling cascades in various cell types.
• Calcium Signaling Research: Employed to inhibit inositol trisphosphate (IP3) production and subsequent intracellular calcium release.
• Pharmacological Profiling: Serves as a reference standard for evaluating the effects of PLC inhibition on cellular responses like secretion and motility.
• Neuroscience Research: Applied in studies of neurotransmitter release and neuronal function where PLC activity is involved.
• Immunology Research: Used to study PLC's role in immune cell activation, such as in T-cells and mast cells.
• Drug Discovery: Acts as a tool compound for validating PLC as a potential therapeutic target in various disease models.

Basic Information

Product Name	U-73122
CAS No.	112648-68-7
Molecular Formula	C₂₉H₄₀N₂O₄
Molecular Weight	480.64 g/mol
Synonyms	1-[6-[[(17β)-3-Methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-1H-pyrrole-2,5-dione; U73122; PLC Inhibitor U-73122; 1-(6-((17β)-3-Methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-2,5-pyrrolidinedione
EINECS	Contact for details

Quality Control

Our U-73122 is manufactured under strict quality control protocols to ensure the highest standards of purity and consistency for research applications. Each batch is analyzed using advanced chromatographic and spectroscopic techniques, including HPLC and NMR, to confirm identity and potency. A comprehensive Certificate of Analysis (COA) detailing purity, assay results, and impurity profiles is provided with every shipment to support your critical research and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and efficacy. Allow the vial to warm to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.