Description

4-Bromo-2-Fluoro-1-Isopropylbenzene is a halogenated aromatic building block of significant importance in advanced organic synthesis. Its value lies in the strategic positioning of bromine and fluorine substituents on the benzene ring, which allows for selective functionalization and modulation of electronic properties in target molecules. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring halogenated aromatic cores for bioactivity or as a handle for further coupling reactions (e.g., Suzuki, Buchwald-Hartwig).
• Agrochemical Synthesis: Used in the development of herbicides, fungicides, and insecticides where the fluorine and bromine atoms contribute to metabolic stability and binding affinity.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromine atom is an excellent leaving group for palladium-catalyzed cross-coupling reactions, making it a versatile scaffold for constructing complex biaryl and heterobiaryl structures.
• Fluorine Chemistry Studies: Acts as a model substrate for investigating the influence of fluorine atoms on aromatic substitution patterns and reaction kinetics.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific halogenated intermediates.

Basic Information

Product Name	4-Bromo-2-Fluoro-1-Isopropylbenzene
CAS No.	112611-87-7
Molecular Formula	C9H10BrF
Molecular Weight	217.08 g/mol
Synonyms	1-Bromo-4-fluoro-2-isopropylbenzene; 2-Fluoro-4-bromoisopropylbenzene; 4-Bromo-2-fluoro-1-(1-methylethyl)benzene; 4-Bromo-2-fluorocumene; (4-Bromo-2-fluorophenyl)propane; 2-Fluoro-α,α-dimethyl-4-bromotoluene; 4-Bromo-2-fluoro-1-isopropyl-benzene
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-Fluoro-1-Isopropylbenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity and consistency, meeting the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and organic solvents. Recommended long-term storage temperature is between 2°C and 8°C. Allow the container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.