Description

Imidazo[1,2-A]Pyridine-3-Sulfonyl Chloride, 2-Chloro- is a high-purity, reactive sulfonyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in enabling the efficient introduction of the sulfonamide functional group, a key motif in modern pharmaceutical and agrochemical discovery. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-quality intermediates for constructing complex heterocyclic molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders, infectious diseases, and oncology.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the bioactivity of the sulfonamide moiety.
• Material Science Research: Employed in the creation of functional polymers, dyes, and photoactive materials where the imidazopyridine scaffold imparts specific electronic properties.
• Chemical Biology & Proteomics: Acts as a reactive handle for labeling proteins or synthesizing activity-based probes (ABPs) due to its electrophilic sulfonyl chloride group.
• Library Synthesis for Drug Discovery: A valuable scaffold for generating diverse compound libraries in high-throughput screening campaigns to identify new lead structures.

Basic Information

Item	Detail
Product Name	Imidazo[1,2-A]Pyridine-3-Sulfonyl Chloride, 2-Chloro-
CAS No.	112566-18-4
Molecular Formula	C7H4Cl2N2O2S
Molecular Weight	251.09 g/mol
Synonyms	2-Chloroimidazo[1,2-a]pyridine-3-sulfonyl chloride; 2-Chloro-3-(chlorosulfonyl)imidazo[1,2-a]pyridine; 2-Chloroimidazo[1,2-a]pyridine-3-sulfonchlorid; Imidazo[1,2-a]pyridine-3-sulfonyl chloride, 2-chloro-; 112566-18-4; 2-Chloroimidazo[1,2-a]pyridine-3-sulfonylchloride
EINECS	Contact for details

Quality Control

Every batch of Imidazo[1,2-A]Pyridine-3-Sulfonyl Chloride, 2-Chloro- undergoes rigorous analytical testing to ensure it meets the stringent purity requirements for synthetic applications. Our quality assurance protocols are designed to guarantee batch-to-batch consistency and reliability. A comprehensive Certificate of Analysis (COA), detailing purity, identity, and impurity profiles as determined by HPLC, NMR, and IR spectroscopy, is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.