Description

Dl-Norepinephrine 3-Sulfate CAS NO 112346-92-6 is a chemically modified derivative of the endogenous catecholamine neurotransmitter, norepinephrine. This sulfate ester form is a critical reference standard and intermediate in pharmaceutical research and development, offering enhanced stability for analytical and synthetic applications. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors for method validation, metabolic studies, and the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Reference Standard: Used for the calibration of analytical instruments (HPLC, LC-MS) to ensure accurate quantification of norepinephrine and its metabolites in drug development and bioanalysis.
• Biochemical Research: Serves as a stable precursor or analog in studies of adrenergic receptor function, neurotransmitter metabolism, and signal transduction pathways.
• Diagnostic Reagent Manufacturing: Employed as a key raw material in the production of enzyme immunoassay (EIA) kits and other in-vitro diagnostic tests for catecholamine levels.
• Metabolite Synthesis: Acts as a crucial intermediate in the organic synthesis of labeled (e.g., deuterated) or other modified catecholamine metabolites for advanced research applications.
• Quality Control: Essential for pharmaceutical QC laboratories to verify the purity and identity of related substances in active pharmaceutical ingredient (API) batches.

Basic Information

Product Name	Dl-Norepinephrine 3-Sulfate
CAS No.	112346-92-6
Molecular Formula	C8H11NO7S
Molecular Weight	265.24 g/mol
Synonyms	DL-Noradrenaline 3-sulfate; (±)-Norepinephrine 3-sulfate; 4-[(1RS)-2-Amino-1-hydroxyethyl]benzene-1,2-diol 3-(hydrogen sulfate); Noradrenaline 3-O-sulfate; Norepinephrine 3-O-sulfate; DL-Arterenol 3-sulfate; 3-O-Sulfo-DL-norepinephrine
EINECS	Contact for details

Quality Control

Our Dl-Norepinephrine 3-Sulfate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and residual solvent analysis, to ensure it meets the stringent requirements for research and development use. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.