Description

2-Chloro-4,5-Difluorobenzotrifluoride is a versatile fluorinated aromatic building block of significant importance in advanced organic synthesis. Its value lies in its trifluoromethyl and halogen substituents, which are key for modulating the electronic properties, lipophilicity, and metabolic stability of target molecules. This compound is primarily needed by R&D and production teams in the pharmaceutical and agrochemical industries for developing new active ingredients.

Application

• Pharmaceutical Intermediate: A critical synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in areas requiring fluorinated motifs for enhanced bioavailability and target binding.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoro and trifluoromethyl groups contribute to efficacy and environmental persistence.
• Liquid Crystal Materials: Serves as a key precursor in the synthesis of fluorinated liquid crystals for high-performance electronic displays.
• Functional Material Development: Employed in creating specialty polymers, coatings, and electronic materials that benefit from the introduction of fluorine atoms for thermal stability and chemical resistance.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution to construct complex, polyfunctionalized aromatic systems.

Basic Information

Product Name	2-Chloro-4,5-Difluorobenzotrifluoride
CAS No.	112290-03-6
Molecular Formula	C7H2ClF5
Molecular Weight	216.54 g/mol
Synonyms	1-Chloro-2,3-difluoro-4-(trifluoromethyl)benzene; 2,3-Difluoro-1-chloro-4-(trifluoromethyl)benzene; 2-Chloro-α,α,α,4,5-pentafluorotoluene; Benzene, 1-chloro-2,3-difluoro-4-(trifluoromethyl)-; 4-(Trifluoromethyl)-2,3-difluorochlorobenzene; 2-Chloro-4,5-difluoro-α,α,α-trifluorotoluene; 2,3-Difluorobenzotrifluoride, 2-chloro derivative
EINECS	Contact for details

Quality Control

Our 2-Chloro-4,5-Difluorobenzotrifluoride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area, away from heat sources and incompatible materials. Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use to prevent evaporation and concentration changes. Recommended storage temperature is 2-25°C.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Individual impurity ≤ 1.0%
Total Impurities	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.