Description

2,2,5,7,8-Pentamethylchroman-6-Sulfonyl Chloride is a specialized sulfonyl chloride derivative of the chroman family, serving as a critical building block in advanced organic synthesis. Its primary value lies in its high reactivity as a sulfonylation reagent, enabling the efficient introduction of the pentamethylchroman-6-sulfonyl protecting group. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries, particularly for the synthesis of complex molecules where selective protection and functionalization are required.

Application

• Pharmaceutical Intermediate: Key reagent in the synthesis of active pharmaceutical ingredients (APIs), especially for introducing sulfonamide or sulfonate ester functionalities.
• Peptide Chemistry: Used as a protecting group agent for specific amino acid side chains during solid-phase and solution-phase peptide synthesis.
• Organic Synthesis Building Block: Employed in the preparation of complex natural products and specialty chemicals where the chroman-sulfonyl moiety is integral.
• Material Science Research: Potential monomer or modifier in the development of novel polymers with specific optical or electronic properties.
• Agrochemical Synthesis: Intermediate in the research and development of new crop protection agents and herbicides.
• Protecting Group Chemistry: Serves as a robust and selectively removable protecting group for alcohols, amines, and other nucleophiles in multi-step syntheses.

Basic Information

Product Name	2,2,5,7,8-Pentamethylchroman-6-Sulfonyl Chloride
CAS No.	112160-39-1
Molecular Formula	C₁₄H₁₉ClO₃S
Molecular Weight	302.82 g/mol
Synonyms	6-Chlorosulfonyl-2,2,5,7,8-pentamethylchroman; 2,2,5,7,8-Pentamethyl-6-chromansulfonyl chloride; PMC-Sulfonyl Chloride; Chroman-6-sulfonyl chloride, 2,2,5,7,8-pentamethyl-; Pentamethylchroman-6-sulfonyl chloride; 6-(Chlorosulfonyl)-2,2,5,7,8-pentamethyl-3,4-dihydro-2H-1-benzopyran
EINECS	Contact for details

Quality Control

Our 2,2,5,7,8-Pentamethylchroman-6-Sulfonyl Chloride is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and production. Certificates of Analysis (COA) detailing all specifications are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.