Description

Argiotoxin 659 is a potent and highly selective glutamate receptor antagonist, specifically targeting the N-methyl-D-aspartate (NMDA) receptor complex. This compound is a critical research tool for neuropharmacological studies, enabling the investigation of excitatory synaptic transmission, neurotoxicity, and neurological disorders. It is essential for academic researchers, pharmaceutical R&D teams, and biotechnology companies focused on neuroscience, pain management, and neurodegenerative disease research. The product is supplied as Argiotoxin 659 CAS NO 111944-83-3, ensuring precise identification for scientific and regulatory purposes.

Application

• Neuroscience Research: A fundamental tool for studying the physiology and pharmacology of ionotropic glutamate receptors, particularly NMDA receptors, in synaptic plasticity and signal transduction.
• Neuropharmacology Screening: Used as a reference standard or active compound in high-throughput screening assays to identify novel neuroprotective agents or receptor modulators.
• Mechanistic Studies of Neurotoxicity: Employed to model and understand excitotoxicity pathways implicated in stroke, traumatic brain injury, and chronic neurodegenerative conditions.
• Patch-Clamp Electrophysiology: Serves as a selective blocker in electrophysiological experiments to characterize receptor currents and channel kinetics in neuronal cells and tissues.
• Biochemical Assay Development: Utilized in the development and validation of competitive binding assays and other in vitro tests for receptor-ligand interaction studies.
• Reference Standard for Analytical Testing: Provides a certified standard for quality control, method development, and quantification in analytical laboratories within the pharmaceutical and life science sectors.

Basic Information

Product Name	Argiotoxin 659
CAS No.	111944-83-3
Molecular Formula	C41H71N13O12
Molecular Weight	914.09 g/mol
Synonyms	Argiotoxin-659; ArgTX-659; AR-659; Philanthotoxin-659; PhTX-659; 4-Hydroxyphenylacetyl-Asn-Trp-Lys-NH2 (sequence-related analog); Glutamate receptor antagonist 659; NMDA receptor non-competitive antagonist 659
EINECS	Contact for details

Quality Control

Every batch of Argiotoxin 659 is produced and analyzed under strict quality management protocols to ensure the highest standards of purity and identity for research applications. Our quality control includes comprehensive analytical testing via HPLC, MS, and NMR to confirm chemical structure and purity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific results for identity, purity, and impurities. We support compliance with relevant research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. Due to its hygroscopic (moisture-sensitive) nature, the container must be sealed under an inert atmosphere or with desiccant and allowed to equilibrate to room temperature before opening to prevent condensation and hydrolysis. For long-term stability, store under argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.