Description

Demethoxyfumitremorgin C is a structurally complex indole alkaloid belonging to the fumitremorgin class of mycotoxins. This compound is of significant interest in biochemical and pharmacological research due to its potent biological activity as an inhibitor of breast cancer resistance protein (BCRP/ABCG2). It serves as a critical research tool for scientists in oncology and drug discovery, particularly for studying multidrug resistance mechanisms and developing novel therapeutic strategies. Key target sectors include pharmaceutical R&D, academic research institutions, and biotechnology companies focused on cancer biology.

Application

• Biochemical Research Tool: Used as a selective and potent inhibitor of the Breast Cancer Resistance Protein (BCRP/ABCG2) transporter in cell-based assays and in vitro studies.
• Oncology & Drug Discovery: Employed to investigate and overcome multidrug resistance (MDR) in cancer cells, aiding in the development of new chemotherapeutic agents.
• Pharmacokinetics Studies: Applied in research to understand the role of ABCG2 in drug absorption, distribution, and excretion.
• Mechanism of Action Studies: Utilized to elucidate the function and inhibition mechanisms of ATP-binding cassette (ABC) transporters.
• Reference Standard: Serves as a high-purity analytical standard for the identification and quantification of fumitremorgin analogs in research samples.
• Toxicology Research: Investigated for its effects as a mycotoxin and tremorgen, relevant to food safety and mycotoxicology studies.

Basic Information

Product Name	Demethoxyfumitremorgin C
CAS No.	111768-16-2
Molecular Formula	C21H23N3O3
Molecular Weight	365.43 g/mol
Synonyms	Fumitremorgin C, Demethoxy; 5,6-Dihydro-6,14-dihydroxy-3-[(1E)-1-propen-1-yl]-14,15-seco-14-oxofumitremorgin C; 14,15-Secofumitremorgin C, 5,6-dihydro-6,14-dihydroxy-3-[(1E)-1-propenyl]-14-oxo-; BCRP Inhibitor (Fumitremorgin C analog); ABCG2 Inhibitor (Demethoxy); 14,15-Seco-14-oxofumitremorgin C derivative
EINECS	Contact for details

Quality Control

Our Demethoxyfumitremorgin C is produced under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Quality is verified against established in-house specifications using advanced techniques including HPLC, NMR, and mass spectrometry. We are committed to supplying materials suitable for critical research applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each batch and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.