Description

3-Bromophenylmagnesium Bromide, 0.50 M In Thf is a crucial organometallic reagent, specifically a Grignard reagent, supplied as a standardized 0.50 M solution in tetrahydrofuran (THF). This product is essential for introducing the 3-bromophenyl moiety in complex organic synthesis, enabling the formation of new carbon-carbon bonds with high precision. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing complex molecular architectures, including active pharmaceutical ingredients (APIs) and specialty chemicals.

Application

• Pharmaceutical Intermediate Synthesis: Key building block for creating complex molecules in drug discovery and development, particularly for APIs.
• Agrochemical Manufacturing: Used in the synthesis of advanced herbicides, fungicides, and insecticides that require specific aryl-bromide functional groups.
• Material Science & Liquid Crystal Production: Employed in the synthesis of organic semiconductors, ligands for catalysts, and liquid crystal compounds.
• Cross-Coupling Reactions: Acts as a nucleophile in palladium-catalyzed reactions such as Kumada, Negishi, and Suzuki-Miyaura couplings.
• Academic & Industrial R&D: A fundamental reagent for methodological development and scale-up studies in organic chemistry laboratories.
• Fine Chemical Production: Used in the manufacture of dyes, pigments, and other high-value specialty organic compounds.

Basic Information

Product Name	3-Bromophenylmagnesium Bromide, 0.50 M In Thf
CAS No.	111762-31-3
Molecular Formula	C6H4BrMgBr (in solution as C6H4BrMgBr • xTHF)
Molecular Weight	260.21 g/mol (for C6H4BrMgBr)
Synonyms	(3-Bromophenyl)magnesium bromide; m-Bromophenylmagnesium bromide; 3-Bromophenyl Grignard reagent; Magnesium, bromo(3-bromophenyl)-; 1-Bromo-3-(bromomagnesio)benzene; Grignard Reagent, 3-Bromophenyl-; m-Bromophenylmagnesium bromide solution; 3-Bromophenylmagnesium bromide THF solution
EINECS	Contact for details

Quality Control

Our 3-Bromophenylmagnesium Bromide solution is manufactured under stringent quality control protocols to ensure batch-to-batch consistency and reliability for critical synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing concentration, purity, and stability parameters. Our quality system is designed to meet the exacting standards required for GMP-intermediate manufacturing and high-purity research.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C (refrigerated) to maintain solution stability and concentration. The product is highly volatile (THF solvent) and easily oxidized; ensure containers are sealed and handled in a dry, inert environment to prevent degradation and moisture ingress. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	Clear, colorless to light yellow solution
Concentration	0.50 M in THF (nominal)
Assay (Titration)	0.45 - 0.55 M
Identification (IR/NMR)	Conforms to structure
Water Content (Karl Fischer)	< 100 ppm
THF Purity (GC)	> 99.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.