Description

Meosuc-Ala-Ala-Pro-Ala-Chloromethylketone is a specialized peptide-based chloromethyl ketone inhibitor, a key tool compound in biochemical and pharmaceutical research. Its primary value lies in its potent and selective inhibition of serine proteases, enabling precise study of enzymatic mechanisms and pathways. This product is essential for researchers and developers in pharmaceutical R&D, proteomics, and enzymology, particularly for investigating inflammation, coagulation, and other critical biological processes.

Application

• Protease Inhibition Research: Acts as a potent, irreversible inhibitor for studying the structure and function of specific serine proteases.
• Drug Discovery & Development: Serves as a key pharmacophore or lead compound in the design of novel therapeutic agents targeting protease activity.
• Biochemical Assay Development: Used to validate assay systems, calibrate equipment, and establish inhibition constants (Ki) for enzymatic studies.
• Mechanism of Action Studies: Employed to elucidate catalytic mechanisms and active site interactions of target enzymes.
• Academic & Industrial R&D: A critical reagent in university laboratories and biotech companies focused on enzymology and signal transduction.

Basic Information

Product Name	Meosuc-Ala-Ala-Pro-Ala-Chloromethylketone
CAS No.	111682-13-4
Molecular Formula	C22H34ClN5O8
Molecular Weight	532.0 g/mol (approx.)
Synonyms	MeOSuc-AAP-A-CMK; Methoxysuccinyl-Ala-Ala-Pro-Ala-Chloromethyl Ketone; MeOSuc-Ala-Ala-Pro-Ala-CH2Cl; AAPACMK; Serine Protease Inhibitor AAPACMK; NSC 364372; (2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[4-Methoxy-4-oxobutanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]propanoyl]amino]-4-chloro-1-oxobutan-2-yl acetate
EINECS	Contact for details

Quality Control

Our Meosuc-Ala-Ala-Pro-Ala-Chloromethylketone is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to rigorous analytical standards, utilizing techniques such as HPLC, NMR, and MS for verification to meet the exacting requirements of the life science research community.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.