Description

S-(1,2,2-Trichlorovinyl)Glutathione is a specialized glutathione conjugate, a key metabolite formed in the detoxification pathway of trichloroethylene and related chlorinated solvents. This compound is of significant interest for its role as a biochemical marker in toxicology and environmental health studies. It is primarily utilized by research institutions, analytical laboratories, and pharmaceutical companies engaged in metabolic profiling, biomarker discovery, and the investigation of chemical toxicity mechanisms.

Application

• Biochemical Research: Used as a reference standard and reagent in studies of glutathione S-transferase (GST) mediated metabolism and detoxification pathways.
• Toxicology & Biomarker Analysis: Serves as a critical analytical standard for the detection and quantification of trichloroethylene metabolites in biological samples (e.g., urine, blood) for occupational and environmental exposure assessment.
• Pharmaceutical Development: Employed in preclinical research to understand the metabolic fate and potential nephrotoxicity of halogenated compounds.
• Environmental Science: Applied in research focused on the biodegradation and human biotransformation of chlorinated volatile organic compounds (VOCs).
• Diagnostic Kit Manufacturing: Can be utilized as a calibrant or component in the development of immunoassays or LC-MS/MS kits for specific metabolite testing.

Basic Information

Product Name	S-(1,2,2-Trichlorovinyl)Glutathione
CAS No.	111574-85-7
Molecular Formula	C12H17Cl3N3O6S
Molecular Weight	445.70 g/mol
Synonyms	S-(1,2,2-Trichloroethenyl)glutathione; Glutathione S-(1,2,2-trichlorovinyl) ester; 1-[(2R)-2-[[(2S)-2-[[(2S)-2-amino-2-carboxyethyl]carbamoyl]-2-(1,2,2-trichloroethenylsulfanylmethyl)ethyl]carbamoyl]-1-carboxyethyl]carbamoyl]amino]ethanoic acid; TCVG; S-(1,2,2-Trichloroethenyl)-L-glutathione; (2S)-2-Amino-4-[[(1R)-1-[[(carboxymethyl)amino]-1-oxo-3-[(1,2,2-trichloroethenyl)sulfanyl]propan-2-yl]amino]-4-oxobutanoic acid
EINECS	Contact for details

Quality Control

Our S-(1,2,2-Trichlorovinyl)Glutathione is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the exacting standards required for research and diagnostic applications. A detailed Certificate of Analysis (COA) specifying batch-specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.